Pancreatic adenocarcinoma is the most pervasive form of cancer with high mortality rates. Being obscure at early stages, non-specific symptoms and their onset only in late stages disease lead to detection III–IV on initial diagnistics. Gastrointestinal stromal tumor (GIST) an intramucosal gastrointestinal tract, which a derivate interstitial cells Cajal. The unicity presented clinical case rare...

Malignant gastrointestinal stromal tumor (GIST) consists a rare neoplasm, developing in small intestine and stomach. The presenting manifastations include weakness, weight loss, nausea, melena and anaemia. The present case refers to a 65 years old female patient with a GIST of the ampulla of Vater presenting with obstructive jaundice. Diagnosis was achieved pre-operatively by biopsies collected...

Retroperitoneal E-GIST is a very rare tumor and a total of 58 cases have been reported in the literature (2). The distinction of E-GIST from gastrointestinal stromal tumors (GIST) is made by proving the origin outside the alimentary system and ruling out a concurrent neoplasm in the gastrointestinal tract. In this letter, we aimed to report a very rare form of E-GIST arising from the retroperit...

We report two cases of a Gastrointestinal Stromal Tumor (GIST) synchronous and metachronous, respectively, with pancreatic adenocarcinoma. To our knowledge, this is the first report of a GIST involved 3 years after a ductal pancreatic adenocarcinoma. Data from the literature and our cases seem to suggest that incidental GIST may occur synchronously and metachronously with other cancers more fre...

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial tumor in the gastrointestinal tract. Although GIST occurs mainly in the gastrointestinal tract, it also occurs, rarely, in non-gastrointestinal tract and in this case, it is often named as extra-gastrointestinal stromal tumor (EGIST). We experienced a 68-year-old male patient who had been diagnosed preoperatively with accid...

Gastrointestinal stromal tumors (GIST) are the most common adult sarcomas and the oncogenic driver is usually a KIT or PDGFRA mutation. Although GISTs are often initially sensitive to imatinib or other tyrosine kinase inhibitors, resistance generally develops, necessitating backup strategies for therapy. In this study, we determined that a subset of human GIST specimens that acquired imatinib r...

Gastrointestinal stromal tumors (GIST) are defined as mesenchymal of the gastrointestinal tract expressing proto-oncogene protein CD 117. GIST is a rare tumor small bowel, which can be difficult to diagnose and has varied clinical outcome. Prognosis dependent on size mitotic count. Radical surgical excision (R0) treatment choice for resectable non-metastatic disease. Imatinib first-line therapy...

Abstract Gastrointestinal stromal tumors (GIST) harboring activating mutations of PDGFRA respond to imatinib, with the notable exception most common mutation, D842V. Avapritinib is a novel, potent KIT/PDGFRA inhibitor substantial clinical activity in patients D842V genotype. To date, only minority PDGFRA-mutant treated avapritinib have developed secondary resistance. Tumor and plasma biopsies 6...

During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which triggers the phenotypic conversion of progenitor smooth muscle cells to tumor-promoting cells. These ...

Authors present the case (from the year 2003) of a 38 years old patient, female with large tumor in the abdominal cavity. Preoperative differential diagnostic examination showed either tumor of pancreas or left liver lobe. The surgery confirmed large tumor body of the pancreas. Histological and immunohistochemical examination determined gastrointestinal stromal tumor (GIST) of the pancreas from...