Most cell cycle regulation research has been conducted in model organisms representing a very small part of the eukaryotic domain. The highly divergent human pathogen Giardia intestinalis is ideal for studying the conservation of eukaryotic pathways. Although Giardia has many cell cycle regulatory components, its genome lacks all anaphase-promoting complex (APC) components. In the present study...

Giardia intestinalis is the etiological agent of giardiasis, a common human intestinal disease with 280 million cases per year. Giardiasis is typically treated with the broad-range antibiotic metronidazole; however, the emergence of drug-resistant strains calls for the development of new anti-parasitic drugs. Very little is known regarding the molecular mechanisms adopted by Giardia to cope wit...

Opinions are divided regarding the pathological manifestations of the flagellates. Alvarez, Silverton and Bernardino are of opinion that the fact that the infection as well as the symptom disappeared after treatment with atebrin proved beyond doubt the pathogenicity of the flagellates. Chopra et al. (1939) from a routine study of the stools of the patients, the symptoms and the response to trea...

Cultivation of luminal protistan parasites has a long history. In this review we discuss the methods and media that are most widely used for the establishment and maintenance of the following organisms in culture: Entamoeba histolytica, Giardia intestinalis, Trichomonas vaginalis, Dientamoeba fragilis, Blastocystis hominis, and Balantidium coli. While cultivation is of limited importance in the...

Assistant Surgeon, Medical College Hospital, Calcutta, ortnerly Clinical Pathologist, Protozoology Depart-' ment, Calcutta School of Tropical Medicine.) The; role which Giardia inrcsnnuus may 'n the production of intestinal symptoms is still a disputed point. Nothing very definite can be stated one way or the other. It is claimed on the one hand' that it is frequently present in healthy persons...

BACKGROUND Present study aimed to investigate prevalence of Giardia intestinalis and Hymenolepis nana in Afghan refugees visiting Central Health Unit (CHU), Kot Chandana (Mianwali, Northern Punjab) during two years period (February 2007 to December 2009). METHODS A total of 687 stool samples were collected from different age groups of both genders. Samples were processed under sterile conditi...

Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a predominant cause of waterborne diarrheal disease that may lead to post-infectious functional gastrointestinal disorders. Although Giardia-infected individuals could carry as much as 106 trophozoites per centimetre of gut, their intestinal mucosa is devoid of overt signs of inflammation. Recent studies have shown that in endemic countri...

Trypanosoma cruzi and Giardia intestinalis are two human pathogens and protozoan parasites responsible for the diseases Chagas disease and giardiasis, respectively. Both diseases cause suffering and illness in several million individuals. The former disease occurs primarily in South America and Central America, and the latter disease occurs worldwide. Current therapeutics are toxic and lack eff...

BACKGROUND Asymptomatic carriage of Giardia intestinalis is highly prevalent among children in developing countries, and evidence regarding its role as a diarrhea-causing agent in these settings is controversial. Impaired linear growth and cognition have been associated with giardiasis, presumably mediated by malabsorption of nutrients. In a prospective cohort study, we aim to compare diarrhea ...