Giant cell myocarditis is a serious and frequently fatal inflammatory heart disease of which the etiology remains unknown. In the present study, we investigated the origin of multinucleated giant cells in myocarditis with the use of an experimental model. We also examined the factors relating to the formation of giant cells in myocarditis. Severe myocarditis characterized by the appearance of m...

background: although giant cell tumor (gct) is considered to be a primary benign bone tumor, its aggressive behavior makes its diagnosis and treatment, difficult and challenging. this is especially true in distal radius where gct appears to be more aggressive and difficult to control locally. we report our clinical outcome of en-block resection and reconstruction with non-vascularized fibular a...

we report occurrence of a rare case of giant cell tumor (gct), in a 28-year old woman, arising from anterior arc of right 6 th rib during pregnancy. it progressed rapidly during breast-feeding period, mimicking malignant bone tumor at delayed presentation.

Inflammatory endobronchial polyp is a rare disease mostly encountered in asthmatic patients. Chronic airway and foreign material irritation or thermal injury may result in the formation of granulated tissues and become polypoid mass. Herein, we describe a 52-year-old man with severe respiratory distress and infection with 35 years history of smoking. He had an obstructive pattern in his pulmona...

BACKGROUND Giant binuclear oocytes occur with considerable frequency in human ovaries, but their ultimate fate remains unknown. We report the morphology, cytogenetics and developmental potential of human giant oocytes from patients undergoing assisted reproductive technologies. METHODS AND RESULTS A total of 44 giant oocytes was collected from patients aged 22-44 years old, with an overall fr...

The zebrafish has become an important genetic model, but their small size makes them impractical for traditional physiological studies. In contrast, the closely related giant danio is larger and can be utilized for physiological studies that can also make use of the extensive zebrafish genomic resources. In addition, the giant danio and zebrafish appear to exhibit different growth types, indica...

Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas (CGCGs) / (PGCGs) an Iranian population. Methods: In this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, ...

Sebaceoma is a benign tumor with sebaceous differentiation. It usually presents as a yellowish papule or nodule on the face and scalp. This is a report of a 27-year-old-woman who presented with a giant, 6cm×4.5 cm exophytic tumor on her head. Clinically, we considered several diseases; however, the histological and immunohistochemical features matched those of sebaceoma. The lesion was excised ...

This paper describes a method to reconstitute GPCRs into an array of giant liposomes in a buffer solution. We first achieved the formation of giant liposomes in a buffer solution by adding fructose to a lipid film; normally such giant liposomes are formed by using only pure waters (MilliQ). Moreover, we successfully reconstituted adrenergic receptors (AR) of GPCRs into the giant liposome array ...

Surgical bullectomy is the treatment of choice for giant emphysematous bullae; however, when a giant emphysematous bulla occupies the entire hemithorax, and the remaining lung is in a collapsed state for a long period, it is difficult to predict the surgical outcome preoperatively. We report a case of the successful resection of a giant emphysematous bulla occupying the entire hemithorax. A 44-...