نتایج جستجو برای: ghrh

تعداد نتایج: 735  

1999
J. GARDI

Gardi, J., F. Obál, Jr., J. Fang, J. Zhang, and J. M. Krueger. Diurnal variations and sleep deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1339–R1344, 1999.—Previous reports indicate that hypothalamic growth hormone-releasing hormone (GHRH) promotes sleep and is involved in sleep regulation. The ai...

Journal: :Yearbook of pediatric endocrinology 2021

These authors report two Mll4 mutant mouse models that exhibited dwarfism and altered development of GHRH−neurons.

Journal: :The Journal of endocrinology 2001
A Pérez-Romero E Dialynas F Salame A Amores L Vidarte A Bartke C Ariznavarreta J A Tresguerres

High local GH-releasing hormone (GHRH) levels are capable of inducing transdifferentiation in salivary cells to synthesize GH. However, the factors implicated in this process remain unknown. To study this subject, normal and Ames dwarf mice were implanted in the submaxillary gland with a slow release pellet releasing 21 microgram GHRH (1-29)-NH(2)/day for 2 months. Control animals received plac...

2012
Roberto Perez Andrew V. Schally Irving Vidaurre Ricardo Rincon Norman L. Block Ferenc G. Rick

This study evaluated the effects of a modern antagonistic analog of GHRH on tumor growth and on expression of inflammatory cytokine genes in two models of human triple negative breast cancers (TNBC). The TNBC subtype is refractory to the treatment options available for other hormone-independent breast cancers. Inflammatory cytokines play a major role in the cellular signaling associated with br...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
F Obál J Fang P Taishi B Kacsóh J Gardi J M Krueger

The somatotropic axis, and particularly growth hormone-releasing hormone (GHRH), is implicated in the regulation of sleep-wake activity. To evaluate sleep in chronic somatotropic deficiency, sleep-wake activity was studied in dwarf (dw/dw) rats that are known to have a defective GHRH signaling mechanism in the pituitary and in normal Lewis rats, the parental strain of the dw/dw rats. In additio...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Miklos Jaszberenyi Ferenc G Rick Petra Popovics Norman L Block Marta Zarandi Ren-Zhi Cai Irving Vidaurre Luca Szalontay Arumugam R Jayakumar Andrew V Schally

The dismal prognosis of malignant brain tumors drives the development of new treatment modalities. In view of the multiple activities of growth hormone-releasing hormone (GHRH), we hypothesized that pretreatment with a GHRH agonist, JI-34, might increase the susceptibility of U-87 MG glioblastoma multiforme (GBM) cells to subsequent treatment with the cytotoxic drug, doxorubicin (DOX). This con...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Eva Szentirmai Tadanobu Yasuda Ping Taishi Mingxiang Wang Lynn Churchill Stewart Bohnet Paul Magrath Bálint Kacsóh Lissette Jimenez James M Krueger

Growth hormone-releasing hormone (GHRH), its receptor (GHRHR), and other members of the somatotropic axis are involved in non-rapid eye movement sleep (NREMS) regulation. Previously, studies established the involvement of hypothalamic GHRHergic mechanisms in NREMS regulation, but cerebral cortical GHRH mechanisms in sleep regulation remained uninvestigated. Here, we show that unilateral applica...

2010
Guillaume Osterstock Pauline Escobar Violeta Mitutsova Laurie-Anne Gouty-Colomer Pierre Fontanaud François Molino Jean-Alain Fehrentz Danielle Carmignac Jean Martinez Nathalie C. Guerineau Iain C. A. F. Robinson Patrice Mollard Pierre-François Méry

BACKGROUND Ghrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in the effect of ghrelin on feeding. Interestingly, connections between NPY and GHRH neurons have been reported, leading to the hypothesis that the GH axis and the feeding c...

Journal: :The Journal of clinical endocrinology and metabolism 1998
I Netchine P Talon F Dastot F Vitaux M Goossens S Amselem

GH secretion and release are complex phenomena depending on activation of several genes, including those encoding GH, GHRH, and its receptor (GHRH-R). The GH gene, which is the most extensively analyzed sequence in patients with familial GH deficiency (GHD), represents the main known target of mutations. To test the involvement of the GHRH-R gene in this disease phenotype, we investigated one c...

Journal: :Biological psychiatry 2000
R E Dahl B Birmaher D E Williamson L Dorn J Perel J Kaufman D A Brent D A Axelson N D Ryan

BACKGROUND This study examined growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in a large sample of depressed children compared with normal control children. Within-subject comparisons were also performed in control subjects to examine test-retest reliability and in depressed children comparing episode versus clinical recovery. METHODS The sample included depressed chi...

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