OBJECTIVE This study was undertaken to determine whether the expressions of 3 proliferation markers (Ki-67, proliferating cell nuclear antigen, and silver-staining nucleolar organizer regions) and of p53 tumor protein could differentiate spontaneous abortions from gestational trophoblastic diseases and also discriminate among gestational trophoblastic disease subgroups. STUDY DESIGN Twenty-tw...

Gestational trophoblastic disease (GTD) is a group of tumors defined by abnormal proliferation. GTD divided into hydatidiform moles (contain villi) and other neoplasms (lack villi).1 The malignant forms the are also collectively known as gestational or neoplasia (GTN).GTN includes invasive mole, choriocarcinoma, placental site tumor, epithelioid tumor. Southeast Asia Japan have highest reported...

OBJECTIVE To assess quality of life (QoL) and psychological aspects in patients with gestational trophoblastic disease (GTD). METHODS This cross-sectional self-report study was conducted among 54 women. Validated question-naires assessed QoL (WHO-QOL-bref), symptoms of depression (Beck Depression Inventory [BDI]) and anxiety (State-Trait Anxiety Inventory [STAI]). RESULTS Most patients rate...

Gestational trophoblastic neoplasms are a group of fetal trophoblastic tumors including choriocarcinomas, epithelioid trophoblastic tumors (ETTs), and placental site trophoblastic tumors (PSTTs). Mixed gestational trophoblastic neoplasms are extremely rare. The existence of mixed gestational trophoblastic neoplasms that were composed of choriocarcinoma and/or PSTT and/or ETT was also reported. ...

Gestational trophoblastic diseases (GTD) are a group of originating from the placenta, with significant morbidity and mortality, especially in developing countries. A one-year prospective study on GTD was done to determine incidence identify risk factors; explain clinical presentation; describe management; record outcomes at Orotta Maternity Referral Hospital (OMRH) Asmara, Eritrea; protocol fo...

OBJECTIVE To report the prospective outcomes of medical management of missed miscarriage before 13 weeks' gestation from an Australian cohort. DESIGN Descriptive study of a cohort selected out of a randomised controlled trial. SETTING Outpatient management at a maternity hospital between 1 May 2007 and 28 July 2010. PARTICIPANTS 264 women requesting medical management of missed miscarriag...

BACKGROUND Gestational Trophoblastic Disease comprises a group of benign and malignant disorders that derive from the placenta. Using Leventhal's Common-Sense Model as a theoretical framework, this paper examines illness perception in women who have been diagnosed with this disease. METHODS Thirty-one women diagnosed with Gestational Trophoblastic Disease in a hospital in Italy were asked to ...

AIMS To assess the proliferative activity of gestational trophoblastic disease (GTD) using one of the novel proliferation markers (MCM7) and to determine its prognostic value in hydatidiform mole (HM). METHODS AND RESULTS Immunohistochemical staining for MCM7 was performed on 122 samples of paraffin-embedded trophoblastic tissues including 22 normal first-trimester placentas, 12 term placenta...

We evaluated the effect of GnRH on the serum hCG level in gestational trophoblastic disease (GTD). Five patients with GTD were studied. Three patients had hydatidiform mole (two complete and one partial mole) and two had choriocarcinoma. Blood samples were collected immediately before and 30, 60 min after the 100 μg GnRH iv injection, followed by hCG assay. Only one case of choriocarcinoma demo...

INTRODUCTION Gestational trophoblastic diseases (GTD) are a spectrum of tumors with a various of biological behavior and potential for metastases. It consists of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Choriocarcinoma presents a very aggressive tumor with high malignant potential. CASE REPORT We presented the two cases of choriocarcinoma with br...