objective(s): the link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (gdm), but the underlying mechanisms for this phenomenon are still not clear. reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). some recent studies have provi...

PURPOSE To measure fetal renal volume in normoglycemic and hyperglycemic pregnancies. METHODS A longitudinal prospective study was conducted and included 92 hyperglycemic and 339 normoglycemic pregnant women attended at the prenatal service of a hospital from Rio de Janeiro State. Ultrasound examinations were performed to estimate gestational age at baseline and the kidney volume was estimate...

Background: Both maternal and fetal complications are increased in diabetic pregnancies. Although hypertensive complications are increased in pregnant women with pregestational diabetes, reports on hypertensive complications in women with gestational diabetes mellitus (GDM) have been contradictory. Congenital malformations and macrosomia are the main fetal complications in Type 1 diabetic pregn...

Establishment, progressive development, expansion and organization of Cuba's National Comprehensive Diabetes and Pregnancy Program is described, including changes in related health services since 1959. Currently implemented throughout the country, the Program is supervised by a working group and addresses diabetic women's reproductive health and care during pregnancy. The importance of preconce...

INTRODUCTION Gestational diabetes is the most common metabolic disorder in pregnancy, and lack of self-care is the most important reason for mortality in diabetic patients. Since the glycemic control is associated with physiological and psychological mechanisms, variables such as health locus of control can play a role in health behaviors of diabetic patients. Therefore, this study was aimed to...

OBJECTIVES The current study sought to identify macroscopic placental changes associated with clinical conditions in women with or without diabetes and their newborns. METHODS The study population consisted of 62 pregnant women clinically diagnosed with diabetes and 62 healthy women (control group). RESULTS Among the subjects with diabetes, 43 women (69.3%) were diagnosed with gestational d...

Continuous Glucose Monitors (CGMs) provide tremendous value for diabetes detection and management. However, their high cost regulatory complications have prevented the widespread use of CGMs. On other hand, Heart Rate (HR) monitors are in wide growing popularity. In this work, we investigate connection between HR monitor CGM devices to find a cheaper alternative measuring glucose dysregulation....

OBJECTIVES The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. MATERIALS AND METHODS In this experimental study, 12 Wistar rat dams were ra...

The results of management of 128 consecutive pregnancies occurring in diabetic patients who received insulin from before conception and throughout pregnancy are described. Mean maternal blood glucose levels were at least 1 mmol/litre greater than levels reported in normal pregnancy. Thirty-nine percent of the neonates had significant morbidity; respiratory distress syndrome (7.7%), hypocalcaemi...

The incidence of Down's syndrome was studied in 1870 infants of diabetic mothers out of 22,300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for diabetes and all cases of Down's syndrome were confirmed by chromosome analysis. Down's syndrome (all trisomy 21) was diagnosed in 35 infants: seven were born to mothers with gestational diabetes an...