Carbamazepine is widely used for the treatment of epilepsy, trigeminal neuralgia and psychiatric disorders. However, therapy often ineffective, some patients experience adverse drug reactions, which negatively affect both efficacy safety therapy.
 This review systematized presented up-to-date information regarding pharmacokinetics pharmacogenetics carbamazepine, as well most common reactio...

Augmenting immunogenicity by genetically modifying tumor cells to express costimulatory molecules has proven to be a promising therapeutic strategy in murine tumor models and is currently under investigation in human clinical trials for metastatic cancer. However, there are significant technical and logistic problems associated with implementing strategies requiring direct gene modification of ...

This document provides an opinion of the Scientific Panel on Genetically Modified Organisms (GMO Panel) of the European Food Safety Authority (EFSA) on genetically modified maize MON 863 and the maize hybrid MON 863 x MON 810. The opinion is based on two questions raised by the Commission related to applications for the placing of the maize on the market by Monsanto under the Novel Food Regulat...

1.1 Purpose The use of genetically modified organisms (GMOs) in agriculture is rising, but not without debate. There are many scientists who argue that genetic engineering in agriculture is the best way to solve many issues of poverty, food security, environmental harm, and the need for increasing competitiveness in sales, but others raise ethical issues regarding the health of the people who c...

In most countries, systems are in place to analyse food products for the potential presence of genetically modified organisms (GMOs), to enforce labelling requirements and to screen for the potential presence of unauthorised GMOs. With the growing number of GMOs on the world market, a larger diversity of methods is required for informative analyses. In this paper, the specificity of an extended...

Genetically modified organisms (GMOs) can be defined as organisms in which the genetic material (DNA) has been altered in a way that does not occur naturally. The technology is often called “modern biotechnology” or “gene technology”, sometimes also “recombinant DNA technology” or “genetic engineering”. It allows selected individual genes to be transferred from one organism into another, also b...