background: immunization campaign is one of the most effective acts for improving community health, yet under immunized groups, leave communities at risk for vaccine -preventable diseases. the objective of the present study is to assess status of immunization for children under 2 years old in shahriar, iran. methods: this research is a cross- sectional study. cluster sampling was used to select...

in this study, we assessed the adverse reactions to influenza vaccination in hiv- infected individuals. from november 2006 to january 2007, a total of 203 hiv-infected persons were recruited. demographic data were collected. subjects were evaluated 48 h and 15 days after vaccination for symptoms and significant health events as possible side effects. participants were instructed to measure thei...

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mendelian susceptibility to mycobacterial diseases (msmd) is a rare inheritance syndrome, characterized by a disseminated infection with mycobacterium in children following bcg vaccination at birth. regarding the vaccination program in iran, it may consider as a public health problem. the pathogenesis of msmd is dependent on either insufficient production of ifn-gamma (γ) or inadequate response...

A major QTL for host response to porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) infection was identified in a previous study. Single nucleotide polymorphism WUR10000125 (WUR), which is in complete linkage disequilibrium with the putative causative mutation, can be used as a tag SNP for the QTL. However, the effect of WUR following PRRS vaccination and/or coinfection with oth...

INTRODUCTION Bacille Calmette-Guerin (BCG) vaccination remains a routine immunization in primary care in tuberculosis (TB)-endemic areas, though several studies found that its efficacy was inconclusive. Natural resistance-asociated machrophage protein 1 (NRAMP1) polymorphism has been shown to result in higher susceptibility to TB. Information on genetic susceptibility in populations will be use...

Background: Vaccination and immunosuppression are two processes that work in diametrically opposite ways creating an interesting paradox in the immunosuppressed individual. Though influenza vaccination has proven to be useful in allograft recipients the efficacy varies widely in different organ transplants withoverall lower antibody response as compared to the general population. Methods: Syste...

BACKGROUND Antigen-specific anti-tumor vaccines have demonstrated clinical efficacy, but immunological and clinical responses appear to be patient-dependent. We hypothesized that naturally-occurring differences in amino acid sequence of a host's target antigen might predict for immunological outcome from genetic vaccination by presentation of epitopes different from the vaccine. METHODS Using...

OBJECTIVES Antigen-induced activation and proliferation of HIV-1-infected cells is hypothesized to be a mechanism of HIV persistence during antiretroviral therapy. The objective of this study was to determine if proliferation of H1N1-specific HIV-infected cells could be detected following H1N1 vaccination. METHODS This study utilized cryopreserved PBMC from a previously conducted trial of H1N...