Background: Metabolic syndrome (MetS) is characterized by a combination of cardio-metabolic risk factors. Given that genetic factors have been shown to contribute to individual susceptibility to MetS, the identification of genetic markers for disease risk is essential. Recent studies revealed that rs780094 and rs1260326 of glucokinase regulatory gene (GCKR) are associated with serum triglycerid...

The purpose of the study was to detect the AluI and DdeI polymorphisms within POU1F1 gene exon 6 and 3'UTR region in Turkish sheep breeds, and their association with milk productive traits. Jugular blood samples were collected from 50 Sakiz, 50 White Karaman, and 50 Awassi sheep using EDTA as an anticoagulant. PCR-RFLP and sequencing analysis were performed to investigate possible polymorphisms...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...

background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...

Abstract Background To determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy. Methods In total, 352 patients before after treatment 48 healthy individuals were enrolled in this study. detected by Quantimetrix Lipoprint System. The 11 gene polymorphisms— HTR3B (rs2276307, A > G), APOE (rs7412, c.526C T), (rs429358, c.388 T C), CYP2C9*3 (rs1057910, c.1075A ...

background: previous studies revealed that selectins play key roles in homing of immune cells to inflamed tissues and lymphatic organs. l-selectins are expressed on immune cells and interact with p and e selectins to homing to the tissues, hence, the polymorphisms within the gene of l-selectins may are associated with alteration in its expression. thus, the current cross-sectional analytical st...

This study was conducted to identify the polymorphism of ATP1A1 gene, distribution ratios, and its association with semen characteristics Holstein bulls. Twenty-five bulls were used currently. Blood samples collected via venipuncture separate DNA gene. Semen using an artificial vagina for fresh evaluation. Results showed change cytosine (C) nucleotide at site 15738 adenine (A) exon 17 (SNP C157...