Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested. U266 cell proliferation decreased to 61.5 and 54.0% of the control after incubation with 500 n...

The use of next-generation tyrosine kinase inhibitors has led to improved progression-free survival for patients with metastatic non–small cell lung cancer (NSCLC) and those EGFR -mutant ALK -positive tumors. Newer therapeutics can now target KRAS G12C mutations, exon 20 insertions, ERBB2 ( HER2) mutations. Patients NSCLC should undergo molecular testing these mutations as well BRAF mutations; ...

Összefoglaló. A molekuláris diagnosztikai módszerek folyamatos fejlődésének köszönhetően egyre több onkogén genetikai eltérést azonosítanak. neurotrofikus tropomiozin receptor-tirozin-kináz ( NTRK -) génfúziók fontos precíziós onkológiai célpontok, melyek mindhárom -génben előfordulhatnak, onkogén-hajtóerőként viselkednek. különböző módszerekkel azonosíthatók, közül a legpontosabb, legköltséges...

Three rat sarcoma (RAS) gene isoforms, KRAS, NRAS, and HRAS, constitute the most mutated family of small GTPases in cancer. While development targeted immunotherapies has led to a substantial improvement overall survival patients with non-KRAS-mutant cancer, RAS-mutant cancers have an poorer prognosis owing high aggressiveness tumors. KRAS mutations are strongly implicated lung, pancreatic, col...

Tumor heterogeneity and constant selection of therapy-resistant cancer cells in the tumor require combinatorial approaches to treatment that affect various vital processes tumor. Immunotherapy made a revolution among treatment. Today, many methods are grouped around this type Most antitumor immunotherapeutic agents administered intravenously, which cause serious, often life-threatening, side ef...

Abstract With the rapid development of biotechnologies and deep improvement knowledge, “Discovery” is initial period source innovation clinical translational medicine. The international journal Clinical Translational Discovery serves to highlight unknown or unclear aspects medicine‐associated technologies, mechanisms, therapies ( https://onlinelibrary.wiley.com/journal/27680622 ). aims define i...

Herbicide resistance in weeds, including corn poppy (Papaver rhoeas L.), is an increasing problem compromising global crop production. The aims of this study were to evaluate the susceptibility P. populations Poland acetolactate synthase (ALS) inhibitors and elucidate their mechanisms resistance. Between 2017 2020, 157 seed samples collected nationwide a dose-response with various ALS-inhibitin...

The interest on personalized medicine encourages researches pharmacogenetics. promotion of new analytical combinations in extensive drug development and also with the progression technologies for human gene cloning resulted a great In last years genetical sciences influenced Personalized includes areas such as stratified precision these terms are closely related Moderate response rates differen...

introduction: in patients with uncomplicated primary hypertension (htn), angiotensin converting enzyme inhibitors (aceis) are considered as monotherapy. in some studies, cough was not related to age, sex, underlying disease, or drug dosage. however, in previous studies, the incidence of cough was greater in females than males. the aim of this study is to determine the incidence of captopril-ind...