UNLABELLED In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene expression, replicative fitness, and cytopathology. rr-NCCRs result from various deletions and duplications of archetype NCCR (ww-NCCR) sequences, which alter transcription factor binding sites (TFBS). Howe...

In The industry has always focused to devise engineering methodologies for establishment and modification of relatively easier methods for any exhaustive process. A number of different technologies have been developed suitable for the detection of the motion or presence of a target at shorter or longer distances. Most of them make use of a small portion of the electromagnetic spectrum, usually ...

Background: The Archetype formalism and the associated Archetype Definition Language have been proposed as an ISO standard for specifying models of components of electronic healthcare records as a means of achieving interoperability between clinical systems. This paper presents an archetype editor with support for manual or semi-automatic creation of bindings between archetypes and terminology ...

BACKGROUND One of the primary obstacles to the widespread adoption of openEHR methodology is the lack of practical persistence solutions for future-proof electronic health record (EHR) systems as described by the openEHR specifications. This paper presents an archetype relational mapping (ARM) persistence solution for the archetype-based EHR systems to support healthcare delivery in the clinica...

Rearrangements of the JC virus (JCV) regulatory region (RR) are consistently found in the brains of patients with progressive multifocal leukoencephalopathy (PML), whereas the archetype RR is present in their kidneys. In addition, the C terminus of the large T antigen (T-Ag) shows greater variability in PML than does the rest of the coding region. To determine whether similar changes in simian ...

Benthic infaunal species and communities have been extensively used to evaluate quality of the marine environment. Within the MSFD, community composition is addressed most commonly through Descriptor 6 (Seafloor integrity), criterion 6.2 (Condition of benthic communities). At the same time, the Directive has stipulations for addressing and assessing indicators linked with pressures in an explic...

INTRODUCTION This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND The proliferation of archetypes as a means to represent information of Electronic Health Records has raised the need of binding terminological codes - such as SNOMED CT codes - to their elements, in order to identify them univoc...