Background: Previous studies have suggested a causative role for agonists of the aromatic hydrocarbon receptor (AhR) in the etiology of breast cancer 1, early-onset (BRCA-1)–silenced breast tumors, for which prospects for treatment remain poor. Objectives: We investigated the regulation of BRCA1 by the soy isoflavone genistein (GEN) in human estrogen receptor a (ERa)–positive Michigan Cancer Fo...

Gentamicin (GEN) is an aminoglycoside antibiotic with a potent antibacterial activity against a wide variety of bacteria. However, its poor cellular penetration limits its use in the treatment of infections caused by intracellular pathogens. One potential strategy to overcome this problem is the use of particulate carriers that can target the intracellular sites of infection. In this study GEN ...

Abel, J. J. & Geiling, E. M. K. (1925). J. Pharmacol. 25,423. Bergmann, M., Fruton, J. S. & Pollok, H. (1939). J. biol. Chem. 127, 643. Blatherwick, N. R., Bischoff, F., Maxwell, L. C., Berger, J. & Sahyun, M. (1927). J. biol. Chem. 72, 57. Brand, E. & Kassell, B. (1941-2). J. gen. Physiol. 25, 167. du Vigneaud, V. (1927). J. biol. Chem. 75, 393. Fruton, J. S. (1946). J. biol. Chem. 166, 721. G...

BACKGROUND AND OBJECTIVES The authors produced a historical analysis of nine anesthesia-related premises described in the Bible more than 3,500 years ago (Old Testament). Anesthetic drugs and adjuvants, patients, anesthesiologists attitudes and techniques are discussed in the light of Biblical and modern science. CONTENTS To help understanding, the nine premises evaluated are correlated to th...

The role of diet in the prevention of breast cancer is widely accepted, yet little is known about how its biological effects mitigate susceptibility to this disease. Soy consumption is associated with reduced breast cancer risk in women, an effect largely attributed to the soy isoflavone genistein (Gen). We previously showed reduced incidence of chemically induced mammary tumors in young adult ...

Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Genistein (GEN) is an abundant, naturally occurring isoflavonoid found in soy products that has been demonstrated to increase the anti-neoplastic activity of certain chemotherapy drug...

Revision of the Neotropical genera of the subtribe Anthaxiina Gory & Laporte, 1839 (Coleoptera, Buprestidae, Buprestinae, Anthaxiini). Five new genera are described: Anthaxita gen. n., Charlesina gen. n., Cobosina gen. n., Marikia gen. n. and Sanchezia gen. n. Genus Agrilaxia Kerremans, 1903 is divided into two subgenera: Agrilaxia and Costiptera subgen. n. and the genus Bilyaxia Hołyński, 1989...

A perforated patch recording method was used to determine the effects of genistein (Gen), a protein tyrosine kinase (PTK) inhibitor, on basal L-type Ca2+ current ( I Ca,L) in feline atrial myocytes. Gen (50 μM) elicited biphasic changes in I Ca,L: an initial inhibition (-55 ± 4%; phase 1) followed by a secondary stimulation (34 ± 9%; phase 2) of I Ca,L. Withdrawal of Gen elicited a further pote...

Genistein (GEN) is an isoflavone known to inhibit both tyrosine protein kinases and DNA topoisomerase II. The effects of GEN on cell proliferation and cell cycle kinetics of human myelogenous leukemia HL-60 and lymphocytic leukemia MOLT-4 cell cultures were studied, and the data were compared to results obtained with normal human lymphocytes stimulated to proliferate with phytohemagglutinin. GE...

Wang, Yong G., and Stephen L. Lipsius. Genistein elicits biphasic effects on L-type Ca21 current in feline atrial myocytes. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H204–H212, 1998.—A perforated patch recording method was used to determine the effects of genistein (Gen), a protein tyrosine kinase (PTK) inhibitor, on basal L-type Ca21 current (ICa,L) in feline atrial myocytes. Gen (50 μM) ...