نتایج جستجو برای: gelucire 4414

تعداد نتایج: 170  

Journal: :Forests 2021

With the tolerance of flooding and strong winds, Taxodium has been widely recognized as an ecologically important tree in China. Red blight disease, caused by fungal pathogen Pestalotiopsis maculans, is known one most severe leaf diseases Taxodium. However, limited information available regarding host plant defense response to this pathogen. To uncover mechanism plant–pathogen interaction, we p...

2013
Amrinder Singh K. K. Jha Anuj Mittal Amit Kumar

Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT1) receptor that is indicated for the treatment of essential hypertension. It selectively inhibits stimulation of the AT1 receptor by angiotensin II without affecting other receptor systems involved in cardiovascular regulation. Very high lipophilicity a unique feature of telmisartan coupled with a high...

Journal: :Molecules 2016
Lacramioara Ochiuz Cristian Grigoras Marcel Popa Iulian Stoleriu Corneliu Munteanu Daniel Timofte Lenuta Profire Anca Giorgiana Grigoras

The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles, hydrophilic/lipophilic emulsions and liposomes. In the current study, we present our most recent advances in the preparation of alendronate (AL)-load...

Journal: :Pharmaceutics 2023

Ophthalmic drops for ocular delivery exhibit inadequate residence time, which often requires multiple daily dosing that may result in patient non-adherence. In this study, the development of a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) was undertaken. Melt emulsification and ultrasonication were used to manufacture MTZ-loaded SLN, subsequently c...

Journal: :International Journal of Applied Pharmaceutics 2022

Objective: The aim of this investigation was to enhance the solubility and bioavailability BCS class II poorly water-soluble drug ambrisentan by solid dispersion (SD) techniques using Gelucire 50/13 as a hydrophilic carrier. Methods: Solid prepared kneading method different dug: carrier ratios. Prepared SD characterized for solubility, content, percentage yield, in vitro dissolution, ex vivo pe...

Journal: :Indian Journal of Pharmaceutical Sciences 2022

Etravirine is an antiviral belonging to biopharmaceutics classification system class IV due low aqueous solubility and poor permeability. In this study, augment the dissolution profile of etravirine, solid lipid nanoparticles have been formulated by utilizing mixture Compritol® 888 ATO Gelucire® 50/13 as lipids poloxamer 188 surfactant hot homogenization technique. Effect variables, ratio lipid...

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