BACKGROUND AND METHODS When on the market, microbicides are likely to be used by individuals who do not know their HIV status. Hence, assessment of safety and acceptability among HIV positive men and women is important. Acceptability of Carraguard, the Population Council's lead microbicide candidate was assessed in a Phase I safety study among healthy HIV-positive sexually abstinent women and m...

principal scientist in beauty care product development for Johnson & Johnson, works on reformulating an acne gel cleanser. Johnson & Johnson is one of several companies investing considerable resources to remove specific chemicals from their products © Rebecca Kessler

the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

BACKGROUND Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo. METHODS 40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III mon...

In the synthesis of nanoparticles, phenomenon agglomeration is an undesirable condition because particles formed can be larger. The use surfactants prevent occurrence this phenomenon. study, was studied in nanosilica from geothermal sludge. method applied sol-gel method. A 1 M sodium hydroxide (NaOH) solution used to prepare sol phase, while gel phase prepared at pH 5 using a 1.5 hydrochloric a...

This research was aimed to determine the effect of addition aloe vera gel toward characteristic skin lotion and best gel. used a completely randomized design (CRD) consisiting 5 treatments 3 replications. Data were analyzed statistically using ANOVA followed by Duncan’s New Multiple Range Test (DNMRT) at 5% significance level. Treatment in present is 0 g; 10 15 20 g. The observations result pro...

Skin has become an impressive and idealistic platform for the delivery of drugs compared to other routes. However, the stratum corneum “dead, impermeable barrier devoid of biological activity” to skin had challenged the development of transdermal product, which delivers the drugs directly to the systemic circulation at a controlled rate. Recent literature suggests the old doctrine, which states...

OBJECTIVE We sought to determine the safety and acceptability of vaginal gel formulation PC-503 among low risk, abstinent women. The active ingredient was 2% pharmaceutical grade lambda carrageenan, a sulphated polymer that is generally recognised as safe by the US Food and Drug Administration. METHODS 35 women in five sites applied 5 ml of the PC-503 gel vaginally once a day for 7 days while...