Power Dissipation of Digital circuits can be reduced by 15% 25% by using appropriate logic restructuring and also it can be reduced by 40% 60% by lowering switching activity. Here, Gate Diffusion Input Technique which is based on a Shannon expansion is analyzed for minimizing the power consumption and delay of static digital circuits. This technique as compare to other currently used logic desi...

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzy...

This paper presents an experimental study of a 4-cylinder, downsized and boosted, spark ignition engine fuelled by either directly injected compressed natural gas (DI CNG) or gasoline (GDI). Three different charge preparation strategies are investigated for both fuels: stoichiometric operation without external dilution, with exhaust recirculation (EGR) lean burn. The performance the optimized D...

Yersinia spp. cause gastroenteritis and the plague, representing historically devastating pathogens that are currently an important biodefense and antibiotic resistance concern. A critical virulence determinant is the Yersinia protein kinase A, or YpkA, a multidomain protein that disrupts the eukaryotic actin cytoskeleton. Here we solve the crystal structure of a YpkA-Rac1 complex and find that...

Mammalian neuroglobin (Ngb) protects neuronal cells under conditions of oxidative stress. We previously showed that human Ngb acts as a guanine nucleotide dissociation inhibitor (GDI) for the α-subunits of heterotrimeric Gi/o proteins and inhibits the decrease in cAMP concentration, leading to protection against cell death. In the present study, we used an eukaryotic expression vector driving h...

The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the inhibition of both GDP dissociation and GTP hydroly...

The energy efficiency of Gasoline Direct Injection (GDI) engines is leading to a continuous increase in GDI engine vehicle population. Consequently, their particulate matter (soot) emissions are also becoming concern. As required for diesel engines, meet the limits set by regulations, catalyzed filters considered as an effective solution through which soot could be trapped and burnt out. Howeve...

O objetivo desta pesquisa foi realizar a adaptação cultural e apresentar as evidências de validade do Growing Disciples Inventory (GDI) para língua portuguesa no Brasil cultura brasileira. Para esse trabalho, abordagem quantitativa utilizada Taxonomia COSMIN cultural, seguida da avaliação um comitê especialistas o pré-teste com aplicação inventário 42 adultos, universitários pessoas comunidade....

AIM To investigate the rate, risk factors, clinical course, and treatment outcomes of endophthalmitis following glaucoma drainage implant (GDI) surgery. METHODS A computerised relational database search was conducted to identify all patients who were implanted with Ahmed glaucoma valve (AGV) and developed endophthalmitis following surgery at the King Khaled Eye Specialist Hospital in Riyadh, ...

This article explains a new implementation of efficient D-Flip-Flop (DFF) using Gate-Diffusion-Input (GDI) technique, PowerPC, DSTC, and HLFF. This DFF design allows reducing power-delay product and area of the circuit, while maintaining low complexity of logic design. Performance comparison with other DFF design techniques is presented, with respect to gate area, number of devices, delay and p...