نتایج جستجو برای: gd1
تعداد نتایج: 175 فیلتر نتایج به سال:
While HSV-2 typically causes genital lesions, HSV-1 is increasingly the cause of genital herpes. In addition, neonatal HSV infections are associated with a high rate of mortality and HSV-2 may increase the risk for HIV or Zika infections, reinforcing the need to develop an effective vaccine. In the GSK Herpevac trial, doubly sero-negative women were vaccinated with a truncated form of gD2 [gD2(...
BACKGROUND: Gaucher disease (GD) is an inherited, rare, lysosomal storage disorder caused by a genetic deficiency of glucocerebrosidase. The result is the accumulation of the substrate, glucosylceramide, in the lysosomes of macrophage cells in the liver, spleen, bones, lungs, and other vital tissues. Three subtypes of Gaucher disease are recognized: type 1 (GD1, non-neuropathic), type 2 (GD2, a...
In Gaucher disease (GD), deficiency of lysosomal acid β-glucosidase results in a broad phenotypic spectrum that is classified into three types based on the absence (type 1 [GD1]) or presence and severity of primary central nervous system involvement (type 2 [GD2], the fulminant neuronopathic form, and type 3 [GD3], the milder chronic neuronopathic form). Enzyme replacement therapy (ERT) with im...
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