The neuron-specific phosphoprotein B-50 (Mr 48 kDa, isoelectric point, IEP, 4.5), which is identical to GAP43, is a member of a family of growth-associated proteins. Protein B-50 is a major phosphoprotein in nerve growth cones isolated from fetal rat brain. In a growth cone particulate fraction (GCp), endogenous B-50 phosphorylation is Ca2+-dependent and is unaffected by cAMP. Addition of purif...

This study aimed to evaluate the temperature changes that occurred in the pulp chamber when using GCP Glass Carbomer Fill (GCP) and two different resin-modified glass-ionomer (RGI) restorative materials at different dentin thicknesses. A standardized Class I occlusal cavity with 1 mm or 2 mm dentin thickness was prepared in the extracted human molar teeth. RGI and GCP fills were placed in the c...

The aims of this study were to compare nitric oxide (NO) levels in stimulated whole saliva from individuals with and without generalized chronic periodontitis (GCP), and to evaluate correlations between these levels with a clinical diagnostic parameter. According to specific criteria, 30 individuals were divided into three groups: one comprising individuals without periodontitis (GC), a second ...

Gastritis cystic polyposa/profunda (GCP) is defined as a hyperplastic polyp that contains foci of misplaced foveolar and/or glandular epithelium in the muscularis mucosae or in the deeper portions of the submucosa or the muscularis propria [1-6]. The lesion called polyposa when an intraluminal polyp is present [1,2] and profunda when the cystic lesion located within the submucosa [3] and the bu...

Periodontitis are infections that may cause systemic consequences. Due to that it is important to make an accurate histopathologic diagnosis as soon as possible. The aim of this study was to determine the main changes from the gingival mucosa biopsy taken from generalized chronic periodontitis (GCP) patients by light microscopy (LM) and transmission electron microscopy (TEM). The results were c...

Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects. It is very important to understand the background of the formation of the ICH-GCP guidelines as this, in it...

Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate. Small molecule GCP-II inhibitors increase brain NAAG, which activates mGluR3, decreases glutamate, and provide therapeutic utility in a variety of preclinical models of neurodegenerative diseases wherein excess glutamate is presume...

BACKGROUND Morbidity and even mortality correlate closely with major injury that causes a systemic inflammatory response. Cytokines and bioactive molecules present at the inflammatory site induce this response and regulate neutrophil proinflammatory responses. The CXC chemokines, important for neutrophil recruitment and activation, include interleukin 8 (IL-8), granulocyte chemotactic protein 2...