BACKGROUND Combination therapy with sofosbuvir (SOF) and simeprevir (SIM) is used to treat patients with hepatitis C virus infection. It is currently unknown whether adding ribavirin (RBV) to SOF + SIM, which raises the pill count from two up to eight pills a day, impacts adherence. The aim of this study is to examine the impact of pill count on real-world adherence rates in patients treated wi...

Cell differentiation is generally tightly coordinated with the cell cycle, typically resulting in a nondividing cell with a unique differentiated morphology. The unicellular trichomes of Arabidopsis are a well-established model for the study of plant cell differentiation. Here, we describe a new genetic locus, SIAMESE (SIM), required for coordinating cell division and cell differentiation durin...

We propose here that the Atlantic meridional overturning circulation (AMOC) plays an important role in setting the effective heat capacity of the World Ocean and thus impacts the pace of transient climate change. The depth and strength of AMOC are shown to be strongly correlated with the depth of heat storage across a suite of state-of-the-art general circulation models (GCMs). In those models ...

Ecological Niche Models (ENMs) are increasingly used by ecologists to project species potential future distribution. However, the application of such models may be challenging, and some caveats have already been identified. While studies have generally shown that projections may be sensitive to the ENM applied or the emission scenario, to name just a few, the sensitivity of ENM-based scenarios ...

[1] We compare new observationally-based data sets of Antarctic near-surface air temperature and snowfall accumulation with 20th century simulations from global climate models (GCMs) that support the Intergovernmental Panel on Climate Change Fourth Assessment Report. Annual Antarctic snowfall accumulation trends in the GCMs agree with observations during 1960–1999, and the sensitivity of snowfa...

The advantages of mass spectrometry (MS) in combination with gas chromatography (GC) – in terms of providing both qualitative and quantitative information are well known. However, confident identification and accurate measurement of trace toxic and odorous species at the lowest levels of interest may be compromised by chromatographic anomalies such as; column bleed, extended solvent tails, air ...

In the threshold of the appearance of global warming from theory to reality, extensive research has focused on predicting the impact of potential climate change on water resources using results from Global Circulation Models (GCMs). This research carries this further by statistical analyses of long term meteorological and hydrological data. Seventy years of historical trends in precipitation, t...

Climate sensitivity is generally studied using two types of models. Atmosphere–ocean general circulation models (AOGCMs) include interactive ocean dynamics and detailed heat uptake. Atmospheric GCMs (AGCMs) with slab ocean models (SOMs) cannot fully simulate the ocean’s response to and influence on climate. However, AGCMs are computationally cheaper and thus are often used to quantify and under...

Structured illumination microscopy (SIM) is a method in fluorescence microscopy which works by acquiring a set of images using widefield detection. Each image in the set is made with a different position of an illumination mask, but with no mask in the detection path [1]. Subsequent image processing is used to produce an optically sectioned image (OS-SIM) [2 4], or an image with resolution beyo...