Oral administration of dosage form is the priority for the patients as per its easy administration, economical formulation and various other reasons. Drugs having good absorption in proximal gastrointestinal tract (GIT) part possess bioavailability problem due to less gastric residence time of drug in the stomach. Thus superporous hydrogel (SPH) is a supreme approach to deliver the drug in uppe...

During the past few decades, numerous oral drug delivery systems have been developed to act as drug reservoirs from which the active substance can be released over a specific period of time at a predetermined and controlled rate. It is evident from the recent scientific and patent literatures that an increased interest in novel oral controlled release dosage forms that designed to be retained i...

Conventional oral dosage forms suffer with many disadvantages. To avoid such limitations controlled release dosage forms are preferred. When these controlled release dosage forms administered by oral route retained in the stomach and release the drug in a controlled fashion continuously in gastrointestinal tract [1]. Controlled release systems also suffer with some limitations such as short gas...

This study aimed to develop hydrophilic, gastroretentive matrix tablets of famotidine with good floating and swelling properties. A novel gastroretentive drug delivery formulation was designed using salep, also known as salepi, a flour obtained from grinding dried palmate tubers of Orchis morio var mascula (Orchidaceae family). The main polysaccharide content of salep is glucomannan, highly sol...

Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in healthy human volunteers with replacement of drug polymer complex by barium sul...