Developing drugs to treat gastric acid related illnesses such as ulcers and acid reflux disease is the leading focus of pharmaceutical companies. In fact, expenditure for treating these disorders is highest among all illnesses in the US. Over the last few decades, a class of drugs known as a proton pump inhibitors (PPIs) appeared on the market and are highly effective at abating gastric illness...

background: endoscopic ultrasonography (eus) has a pivotal role in staging and diagnosis of different gastrointestinal (gi) disorders. although this equipment is not readily available and not all gastroenterologists are trained in this technique, the importance and efficacy of this imaging modality is obvious for all gastroenterologists. we report the indications and prevalence of lesions visua...

ETHNOPHARMACOLOGICAL RELEVANCE An ethnopharmacological survey indicated that the leaves of Byrsonima intermedia A. Juss. (Malpighiaceae), a medicinal species commonly found in the Brazilian Cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea. AIM OF THE STUDY The objective of this study was to evaluate the effects of a methanolic extract of Byrsonima int...

概要 佐 藤氏等 は ウ ロペ プシンの測定 は 胃癌 のScreening Filterと して高 く評価 して いる.我 は々 胃症 状 を訴 える 胃,十 二指 腸疾 患,肝 疾患 並 びに,薬 物投与 中の肺 結核症 、 糖尿 病,リ ウマ チ性 疾 患 等の ウ ロペ プシ ンを測定 し,お の おのの 疾患 につ いて検討 し,ウ ロペ プシン排泄機序 に対 して, 胃及 び副 腎機 能の 関連 性 を検 索 した.胃 癌,萎 縮性 胃炎では既 に知 られ てい るご と く低値 を示 し,か つ無酸 が増 加 し,胃,十 二指 腸潰 瘍で はか な りの増加 を示す が,潰 瘍の 性質,す なわ ち潰瘍 の活動 状 態 と思 われ る症 例 は鎮静期 の ものに 比 して よ り高値 を示 した. リウマチ性 疾患,糖 尿病 では治 療 のた めの ホルモ ン剤 の投 ...

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. In-situ gel provides the best way to overcome problems of immediate release and short gastrointestinal residence of liquids. The in situ gel dosage...

several recent reports reveal that patients develop symptoms of gastorintestinal motility disorders after the standard whipple procedure. in the department of propedeutics of surgery at bulgarian medical academy in sofia we observed the same phenomenon in our whipple-operated group of patients. but the pathogenetic mechanism was so far unclear that prompted us to conduct an experimental study i...

Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...

BACKGROUND Nonsteroidal anti-inflammatory drug (NSAID) use has been associated with a reduced risk of colon cancer; further epidemiologic data appear consistent for stomach and esophageal adenocarcinomas. Yet, data on potential confounding effects by upper gastrointestinal tract (UGI) disorders on adenocarcinomas of the UGI are limited. METHODS This study recruited newly diagnosed patients wi...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

TO THE EDITOR: We appreciate the comments from Kang. This study was conducted to further understand the pathophysiological and psychosocial features in functional vomiting (FV). Patients diagnosed as FV should fulfill the Rome III criteria, which does not require the absence of other functional gastrointestinal disorders. Gastrointestinal symptoms in all FV patients were recorded by questionnai...