I most honored to give the Lyman Duff lecture, since Dr. Duff has had such an impact on atherosclerosis research. As many of you may know, one of Dr. Duff's earliest papers, published in 1932, concerned changes in the rabbit aorta related to medial degeneration produced by diphtheria toxin. His first paper on atherosclerosis was his thesis, written in 1935, in which he looked at "Experimental C...