نتایج جستجو برای: gap junction communication

تعداد نتایج: 521782  

Journal: :The Journal of clinical investigation 1995
Y Munari-Silem M C Lebrethon I Morand B Rousset J M Saez

We have studied the role of gap junction-mediated intercellular communication on the steroidogenic response of bovine (BAC) and human (HAC) adrenal fasciculo-reticularis cells in culture to corticotropin (ACTH). Indirect immunofluorescence analyses showed that intact human and bovine adreno-cortical tissue as well as HAC and BAC in culture expressed the gap junction protein connexin43 (also ter...

Journal: :The Biochemical journal 2009
Joell L Solan Paul D Lampe

Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical roles in embryonic development, co-ordinated contraction of excitable cells, tissue homoeostasis, normal cell growth and differentiation. Phosphorylation of connexin43, the most abundant and ubiquitously expressed connexin, has been implicated in the regulation of gap junctional communication at several ...

Journal: :American journal of physiology. Renal physiology 2009
Jian Yao Takashi Oite Masanori Kitamura

The juxtaglomerular apparatus (JGA) is a specialized contact region between the glomerulus and the cortical thick ascending limb that plays an active role in the maintenance of ion homeostasis and control of blood pressure. The JGA accommodates several different cell types, including vascular smooth muscle cells, endothelial cells, mesangial cells, macula densa cells, and renin-secreting juxtag...

Journal: :Circulation research 1992
R D Veenstra H Z Wang E M Westphale E C Beyer

Multiple gap junction proteins (connexins) and channels have been identified in developing and adult heart. Functional expression of the three connexins found in chick heart (connexin42, connexin43, and connexin45) by stable transfection of communication-deficient neuro2A (N2A) cells revealed that all three connexin cDNAs are capable of forming physiologically distinct gap junctions that differ...

Journal: :Cardiovascular research 2004
Cindy W Wong Thomas Christen Brenda R Kwak

Gap junctions, formed by the connexin (Cx) protein family, are intercellular channels that permit the cytoplasmic exchange of ions and small metabolites between neighboring cells, a process called gap junction intercellular communication (GJIC). These channels possess unique properties, including distinctive permeabilities for various signaling molecules, which depend on the connexin member(s) ...

Journal: :Biology of reproduction 1994
J F Wiesen A R Midgley

The process of atresia is an all-or-none phenomenon in that an entire follicle either undergoes atresia or continues along the developmental pathway. The absence of pockets of atresia adjacent to healthy areas of granulosa cells suggests the existence of a coordinating influence within the entire follicular unit during the process of atresia. Gap junctions interconnect the granulosa cells and t...

Journal: :Neuron glia biology 2006
Vanessa Houades Nathalie Rouach Pascal Ezan Frank Kirchhoff Annette Koulakoff Christian Giaume

The high level of intercellular communication mediated by gap junctions between astrocytes indicates that, besides individual astrocytic domains, a second level of organization might exist for these glial cells as they form communicating networks. Therefore,the contribution of astrocytes to brain function should also be considered to result from coordinated groups of cells. To evaluate the shap...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Donglin Bai Cristiane del Corsso Miduturu Srinivas David C Spray

2-Aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-triphosphate receptor modulator, inhibits capacitive current transients measured in normal rat kidney and human embryonic kidney 293 cells, an indication of blocking gap junction channels between these cells. Here, we used the dual whole-cell patch-clamp method to study the actions of 2-APB on gap junction channels formed by selected conne...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Bo He Xuhui Tong Lingzhi Wang Qin Wang Hua Ye Bing Liu Xiaoting Hong Liang Tao Andrew L Harris

PURPOSE Cancer patients are often concurrently treated with analgesics and antineoplastic drugs, yet the influence of analgesic agents on therapeutic activity of antineoplastic drugs is largely unexplored. This study investigates the effects of three commonly used analgesics, which produce analgesia by different mechanisms, on cytotoxicity induced by cisplatin, a widely used antitumor agent, an...

Journal: :Circulation 2011
Anne Angelillo-Scherrer Pierre Fontana Laurent Burnier Isabelle Roth Rocco Sugamele Anne Brisset Sandrine Morel Séverine Nolli Esther Sutter Alexandra Chassot Claude Capron Delphine Borgel François Saller Marc Chanson Brenda R Kwak

BACKGROUND Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to the formation of a stable thrombus are poorly understood. Connexins comprise a family of proteins that form gap junctions enabling intercellular coordination of tissue activity, a process termed gap junctional intercellular communicatio...

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