An alpha-streptococcus brain abscess was produced in five dogs and studied with magnetic resonance (MR) imaging (0.5 T) and computed tomography (CT). Non-contrastand contrast-enhanced CT scans were obtained using gadolinium diethylenetriaminepentaacetic acid (Gd DTPA) for MR imaging and meglumine iothalamate for CT scanning. Each animal was evaluated in the early and later cerebritis stages of ...

BACKGROUND New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopen...

Despite its good resolution, magnetic resonance imaging intrinsically has low sensitivity. Recently, contrast agent nanoparticles have been used as sensitivity and contrast enhancer. The aim of this study was to investigate a new controlled synthesis method for gadolinium oxide-based nanoparticle preparation. For this purpose, diethyleneglycol coating of gadolinium oxide (Gd2O3-DEG) was perform...

This study aimed to investigate the magnetic resonance (MR) signal enhancement ratio (ER) of contrast-enhanced MR angiography (CE-MRA) in normal rats with gadobenate dimeglumine (Gd-BOPTA) using a clinical 3T scanner and an extremity coil. The relaxivities of Gd-BOPTA with saline only and with 4.5% human serum albumin (HSA) were also measured. Compared with Gadolinium diethylenetriaminepentaace...

Cancer detection in early stage using a powerful and noninvasive tool is of high global interest. In this experiment, a small-molecular-weight glucose based derivative of Gd3+-1-(4-isothiocyanatobenzyl) diethylene tri amine penta acetic acid (Gd3+-p-SCN-Bn‐DTPA‐DG) as a novel potential MR imaging contrast agents was synthesized. Gd3+-p-SCN-Bn‐DTPA‐DG was synthesized with reacting of Glucosamine...

A patient with a diploic meningioma is presented. Computed tomography (CT) scan revealed an intradiploic tumor which seemed contiguous at a point to a contralateral, recurrent parasagittal meningioma. On CT, density of the diploic meningioma was similar to that of the parasagittal meningioma, but the contrast study showed that the former enhanced much less than the latter. Magnetic resonance (M...

Introduction: In patients with colorectal cancer, accurate assessment of the size, location and segmental distribution of liver metastases on a per-lesion basis is critical for treatment planning. Diffusion-weighted MR imaging (DW-MRI) has a high sensitivity and specificity for liver metastasis detection [1-3]. Combining DW-MRI with T1-weighted imaging after liver specific contrast medium Magaf...

Recombinant anti‑epidermal growth factor receptor‑internalizing arginine‑glycine‑aspartic acid (anti‑EGFR single‑domain antibody fused with iRGD peptide) protein efficiently targets the EGFR extracellular domain and integrin αvβ/β5, and shows a high penetration into cells. Thus, this protein may improve penetration of conjugated drugs into the deep zone of gastric cancer multicellular 3D sphero...

Introduction MR first pass perfusion imaging has become a valuable clinical tool for the assessment of myocardial perfusion [1]. The increased spin-lattice relaxation rate 1/T1 and dynamic signal enhancement following the intravenous injection of Gd-DTPA was shown [2] to be a linear function of the local gadolinium concentration. However, studies in rat myocardium [3] revealed that the enhancem...

Seven patients with meningiomas and five patients with neuromas were examined with spin-echo sequences on a 0.35-T imaging system. Signal enhancement and relaxation rate increments with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) were evaluated, as well as relaxation rate contributions, indicators of Gd-DTPA accessibility to the tissue water. The average signal enhancement rate wit...