BACKGROUND AND OBJECTIVES The pathogenesis of acquired nephrogenic systemic fibrosis recently described for patients with renal insufficiency and a history of exposition to gadolinium-based magnetic resonance contrast agents is not completely understood. A role for circulating fibroblasts in the fibrosing tissue is hypothetical, and the mechanism of the assumed trigger function of gadolinium re...

Gadolinium(III) complexes are widely used in magnetic resonance imaging (MRI) as water relaxation agents to improve image contrast. Therapeutic gadolinium-containing agents are also known in which the metal complex enhances tumor response to chemotherapeutics such as cisplatin, or, more commonly, acts as a radiosensitizer in the treatment of diseases, such as cancer. Gadoliniummay also play an ...

OBJECTIVES We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM). BACKGROUND The histologic basis of late gadolinium CMR in patients with HCM is unknown. METHODS A 28-year-old male patient with HCM and heart failure underwent late gadolinium enhancement CMR and, 49 days later, heart t...

Nephrogenic systemic fibrosis (NSF) is a rare disease that is mostly reported in patients with chronic kidney disease (CKD) who have received gadolinium as a contrast in imaging techniques. The exact pathogenetic role of renal failure or gadolinium is not known. The aim of this study is to show whether mild-to-moderate renal failure is a risk for NSF as it is described in severe renal failure. ...

BACKGROUND Netrin-1, a secreted laminin-related protein, is known to regulate not only axonal guidance and neuronal cell migration, but also blood-brain barrier integrity and inflammation. Two preliminary studies reported altered serum netrin-1 levels in multiple sclerosis; however, associations with longitudinal clinical and magnetic resonance imaging activity have not been investigated. OBJ...

AIM To review the published literature comparing the diagnostic accuracy of magnetic resonance angiography (MRA) with and without gadolinium in diagnosing renal artery stenosis, using catheter angiography as reference. MATERIALS AND METHODS A meta-analysis was performed of English language articles identified by computer search using PubMed/MEDLINE, followed by extensive bibliography review f...

Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the threat of litigation has vastly altered clinical practice. Most theories concerning the etiology of the fibrosis are grounded in case reports rather than experiment. This has led to the widely accepted conjecture th...

The results of studying the effect central metal ion on stability gadolinium and holmium complexes with 1,10'-phenanthroline-2,9-dicarboxylic acid diamide are presented. obtained values constants turned out to be an order magnitude lower than previously known for these elements 4,7-dichloro-1,10'-phenanthroline-2,9-dicarboxylic diamide. Keywords: spectrophotometry, gadolinium, holmium, contrast...