Jun acts as a signal-regulated transcription factor in many cellular decisions, ranging from stress response to proliferation control and cell fate induction. Genetic interaction studies have suggested that Jun and JNK signaling are involved in Frizzled (Fz)-mediated planar polarity generation in the Drosophila eye. However, simple loss-of-function analysis of JNK signaling components did not s...

Wnt/Wg signaling pathways are of key importance during development and disease. Canonical and noncanonical Wnt/Frizzled (Fz) pathways share a limited number of signaling components that are part of the membrane proximal signaling complex. In Drosophila, Fz and Dishevelled (Dsh) are the only two components known to be involved in both Wnt/beta-catenin and planar cell polarity (PCP) signaling. PC...

The Frizzled (Fz) receptors contain seven transmembrane helices and an amino-terminal cysteine-rich domain (CRD) that is sufficient and necessary for binding of the ligands, the Wnts. Recent genetic experiments have suggested, however, that the CRD is dispensable for signaling. We engineered fz CRD mutant transgenes and tested them for Wg signaling activity. None of the mutants was functional i...

The adult eye of Drosophila is a highly ordered structure composed of about 800 ommatidia, each displaying precise polarity. The planar polarity is reflected in the mirror-symmetric arrangement of ommatidia relative to the dorso-ventral midline, the equator. This arrangement is generated when ommatidia rotate towards the equator and the photoreceptor R3 displaces R4 creating different chiral fo...

The sensory bristles of the fruit fly Drosophila are organized in a polarized fashion such that bristles on the thorax point posteriorly. These bristles are derived from asymmetric division of sensory organ precursors (SOPs). The Numb protein, which is localized asymmetrically in a cortical crescent in each SOP, segregates into only one of the two daughter cells during cell division, thereby co...

The silver crucian carp (Carassius auratus gibelio), a gynogenetic teleost, is a promising model for the study of evolutionary genetics in vertebrates. We identified ten gynogenetic clones (FZ-I~FZ-X) from triploid silver crucian carp, collected from Fangzheng County in Heilongjiang Province, China, using microsatellite markers. The genetic diversity of these gynogenetic clones was analyzed usi...

Due to its high thermal conductivity and favorable machinability, molybdenum–rhenium (Mo–Re) alloys have huge prospects in the field of high-temperature heat pipes. However, weldability Mo–Re has not yet been systematically investigated. Based on an orthogonal test, influence law single-mode fiber laser welding parameters weld profile mechanical properties joints was studied. Furthermore, exist...

Abstract In this paper, we introduce a new class of control functions, namely extended $\mathcal{FZ}$ FZ -simulation and employ it to define contractive condition. We also prove some fixed best proximity point results in the context an M -complete fuzzy metric space. The presented theorems unify, generalize, im...

Abstract The influence of keyhole TIG (K-TIG) welding parameters on the weld geometry and defects a new nickel-based superalloy VDM Alloy 780 alloy were investigated using statistical design experiment, microstructures heat-affected zone (HAZ) fusion (FZ) K-TIG-welded characterized. No cracks are found in FZ HAZ. Travel speed significantly influences minimum width (Wm), face root excess metal, ...