The hybridoma technique has been shown to be a most reproducible method for producing rodent monoclonal antibodies but poor results were obtained when it was used for generating human monoclonal antibodies. For immunotherapy, murine monoclonal antibodies are inadequate, whereas human monoclonal antibodies are virtually indispensable. Cellular, chemical, genetic and molecular methods to generate...

The Breast Committee of the Cancer and Leukemia Group B was formed in 1969 under the direction of James Holland. Initial studies examined combination chemotherapy for advanced disease. Although the committee has continued to conduct studies in patients with advanced disease, adjuvant therapy has been an even more important focus for the past 30 years. Over the past 20 years, studies have focuse...

Hydrological components in a river basin can get adversely affected by climate change in coming future. Manipur River basin lies in the extreme northeast region of India nestled in the lesser Himalayan ranges and it is under severe pressure from anthropogenic and natural factors. Basin is un-gauged as it lies in remote location and suffering from large data scarcity. This paper explores the imp...

“I will not work for the present no more, I am working for the future”said Tesla to journalists gathered in New York City more than seven decades ago. – “The future is mine!” Inventor of alternating current, polyphase engines and generator, reversible magnetic field, radio, teleautomatics, inventor, on whose patents energetics of XX century is properly based, worked alone on explanation of cosm...

Many regions in the world are protected against flooding by a dike, which may be either natural or artificial. We deal with a model for finding the optimal heights of such a dike in the future. It minimizes the sum of the investments costs for upgrading the dike in the future and the expected costs due to flooding. The model is highly nonlinear, nonconvex, and infinite-dimensional. Despite this...

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I discuss the physics prospects at future high–energy ee linear colliders. After summarizing some aspects of these future machines, I will review a few topics in the Standard Model which can be studied at these colliders: top quark, W/Z vector bosons and Higgs particles physics. A brief discussion on the exploration of extensions of the Standard Model such as Supersymmetry and Grand Unified The...