A useful concept for the rational design of antiparasitic drug candidates is the complexation of bioactive ligands with transition metals. In view of this, an investigation was conducted into a new set of metal complexes as potential antiplasmodium and antiamoebic agents, in order to examine the importance of metallic atoms, as well as the kind of sphere of co-ordination, in these biological pr...

Dawley male and female rats (3 , 5 , 6). As NFTA4 (Chart 1) differs from N-[4-5-nitro-2-furyl)-2-thiazolylj formamide only in that the acetyl group replaces the formyl group; and because NFTA is currently being used as an antibiotic in the therapy of human infectious disease, it seemed imperative that NFTA be studied for chronic toxicity and possible carcinogenicity.

Transitional cell carcinomas induced in syngeneic mice by the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) resemble their human counterpart both grossly and histologically and have been used in an animal model to evaluate antitumor drugs for activity in bladder cancer.

The biotransformation of A/-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), a potent urinary bladder carcinogen, was studied in mice. About 82% of radioactivity was excreted as 14C02within 36 hr after intragastric administration of /V-[4-(5-nitro-2-furyl)-2thiazolyl]-[14C]formamide, suggesting its deformylation to 2amino-4-(5-nitro-2-furyl)thiazole (ANFT). The latter was formed in vitro as ...

Glyceraldehyde 3-phosphate dehydrogenase from rabbit muscle reacts rapidly with /3-(2-furyl)acryloyl phosphate (FA-phosphate) in aqueous solutions at neutral pH to yield an active site-specific, spectrophotometrically identitlable /3-(2-furyl)acryloyl enzyme (FA-enzyme). This acyl-enzyme reacts with arsenate, phosphate, and NADH to give p-(2furyl)acrylic acid, FA-phosphate, and P-(2-furyl)acrol...

Mol-ecules of the title compound, C(14)H(10)FN(3)O, are essentially planar and in the crystal structure they form dimers via hydrogen bonds, involving pyrimidinyl N atoms and amino H atoms, about inversion centers. The centroids of the furyl and pyrimidinyl rings are separated by 3.489 (2)Å, indicating π-π stacking inter-actions.

In the title compound, C(18)H(17)N(3)O(4), the furyl and phenyl rings are inclined at almost right angles [85.77 (7) and 63.25 (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra-molecular N-H⋯O hydrogen bonding.

A convenient one-pot Cu(I)-catalyzed strategy for regioselective synthesis of trisubstituted furan derivatives has been developed via (2-furyl) carbene complexes. This process has opened a new synthetic route to a variety of α-carbonyl furans using air as the oxidant affording furans in good yields.

The asymmetric unit of the title compound, C(11)H(9)N(3)O(2), contains two independent mol-ecules: the dihedral angles between the pyridine ring and the furyl ring are 17.00 (16) and 34.12 (15)°. The crystal structure involves inter-molecular C-H⋯O, N-H⋯N and N-H⋯O hydrogen bonds.