Follistatin (FST) and FST-like-3 (FSTL3) are structurally related proteins that bind and neutralize activin and closely related members of the TGFbeta superfamily. Three FST isoforms (FST288, FST303, and FST315) are produced from the Fst gene that are primarily secreted proteins. FSTL3 is secreted, but is also observed within the nucleus of most cells. We used pulse-chase (35)S labeling to exam...

INTRODUCTION Although numerous attempts have been made to create animal models of depression or at least of some pathophysiological aspects, only a few models have been adequately validated. The mouse forced swimming test (FST) is a useful paradigm that is relatively quick and simple to perform. The test is based on the observation that mice, after an initial struggling phase, develop an immobi...

Financial services technologies (FST) are core to the continuous transformation of financial services organizations (FSO). To date, however, there has been a lack of empirical research into FST adoption against the backdrop of the recent financial crisis. The aim of this article is to re-examine how FSO are currently positioned to take advantage of emerging FST. We emphasize that this article i...

Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weaning environmental enrichment (EE). To establish how EE impacts network-level mechanisms of spatial...

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressant class today and exert their effects by increasing synaptic concentrations of serotonin (5-HT). The forced swim test (FST) is the most widely used animal test predictive of antidepressant action. Rationale of the present study was to investigate the acute effects of citalopram on hepatic tryp...

We report the structural and superconducting properties of FeSe0.3Te0.7 (FST) thin films with different thicknesses grown on ferroelectric Pb(Mg1/3Nb2/3)0.7Ti0.3O3 substrates. It was shown that the FST films undergo biaxial tensile strains which are fully relaxed for films with thicknesses above 200 nm. Electrical transport measurements reveal that the ultrathin films exhibit an insulating beha...

An efficient indexing scheme is essentially important for spoken term detection (STD) on large databases, particularly for phone-based systems that have been widely adopted to achieve vocabulary-independent detection. While the finite state transducer (FST) composition provides a standard indexing approach, the n-gram reverse indexing is more flexible in connectivity representation and confiden...

We examined allozyme variation in two camaenid tree snails, Amphidromus atricallosus and A. inversus, across two principal regions of Thailand and from Singapore, plus for A. inversus, one site in peninsular Malaysia. Using horizontal starch gel electrophoresis, 13 allozyme loci (11 polymorphic) were screened for A. atricallosus and 18 (5 polymorphic) for A. inversus. Heterozygosity was higher ...

Feature selection is a subfield of machine learning focused on reducing the dimensionality datasets by performing computationally intensive process. This work presents Parallel-FST, publicly available parallel library for feature that includes seven methods which follow hybrid MPI/multithreaded approach to reduce their runtime when executed high performance computing systems. Performance tests ...