Local adaptations to environmental conditions are of high ecological importance as they determine distribution ranges and likely affect species responses to climate change. Increased environmental stress (warming, extreme drought) due to climate change in combination with decreased genetic mixing due to isolation may lead to stronger local adaptations of geographically marginal than central pop...

Full blown uremic syndrome of chronic kidney disease (CKD) is seldom seen these days due to early initiation of renal replacement therapies (RRT) [1, 2]. Uremic frost is a manifestation of advanced CKD but rarely seen due to effective RRT. We came across a 21-year-old male patient, brought to us with complaints of nausea, anorexia, oliguria and recent onset alteration in sensorium. On physical ...

CMAJ • NOVEMBER 23, 2010 • 182(17) © 2010 Canadian Medical Association or its licensors E800 A62-year-old man with a history of diabetic ne phropathy presented with confusion, generalized swelling and shortness of breath. He had been noncompliant with dialysis therapy and then had been lost to medical follow-up for about six months. On clinical examination, the patient was somnolent and disorie...

Many studies suggest that the sustained activation underlying working memory (WM) maintenance is mediated by a distributed network that includes the prefrontal cortex and other structures (e.g., posterior parietal cortex, thalamus, globus pallidus, and the caudate nucleus). A computational model of WM, called FROST (short for FROntal-Striatal-Thalamic), is proposed in which the representation o...

The purpose of this paper is to determine the exact distribution of the final size of an epidemic for a wide class of models of susceptible–infective–removed type. First, a nonstationary version of the classical Reed–Frost model is constructed that allows us to incorporate, in particular, random levels of resistance to infection in the susceptibles. Then, a randomized version of this nonstation...

Understanding climatic influences on the rates and mechanisms of landscape erosion is an unresolved problem in Earth science that is important for quantifying soil formation rates, sediment and solute fluxes to oceans, and atmospheric CO2 regulation by silicate weathering. Glaciated landscapes record the erosional legacy of glacial intervals through moraine deposits and U-shaped valleys, wherea...