BACKGROUND AND PURPOSE Bipolar affective disorder (BPAD) can have its onset during childhood, but the diagnosis may be difficult to establish on the basis of clinical findings alone. Our purpose was to determine whether proton MR spectroscopy can be used to identify abnormalities in the brain of children with BPAD. METHODS Ten children, ages 6 to 12 years, underwent clinical testing to establ...

In his Salmon Lectures in 1950, Fulton"0 suggested that radical lobotomy should be abandoned in favor of more restricted lesions in the medioventral quadrant of the frontal lobe. Delgado and Rosvold9 and Rosvold and Delgado' have shown that frontal lobe syndrome in the monkey may be produced by electrical stimulation or electrocoagulation of small areas in the head of the caudate nucleus, a str...

A 5-year-old female with SCD presented thunderclap headaches, followed by stabbing headaches after receiving an exchange transfusion and prednisolone. She developed ischemic infarcts in the left parietal right paramedian frontal lobes.

Ideas concerning the functions of the frontal lobes have undergone a radical change during the past few years. The older hypotheses (which are too well known to require discussion here) were based upon certain conditions such as injuries, tumors, or inflammatory lesions of various types, in which the general effects of disease upon the brain as a whole could by no means be excluded. Moreover, i...

Twenty infants with peripheral low density areas over the frontal lobes in CT scans that resembled cortical atrophy or early communicating hydrocephalus are reported. Most cases presented minimal developmental retardation and a slightly bulging fon tanelle. In many cases, peripheral hypodensity over the frontal lobes disappeared and the infants' development eventually reached normal levels with...

| The frontal lobes in the brain are a component of the cerebral system that supports goal-directed behaviour. However, their functional organization remains controversial. Recent studies have reported rostro-caudal distinctions in frontal cortex activity based on the abstractness of action representations. In addition, some have proposed that these differences reflect a hierarchical organizati...

The purpose of this overview is to provide a background for understanding the relation between the biological maturation of the frontal lobes and the development of the psychological concept of executive functions. In the first section, an interactive hierarchical feedback model is presented as a heuristic way of conceptualizing the relationship of the frontal lobes and executive functions to o...

Clinical neuropsychologists have adopted numerous (and sometimes conflicting) approaches to the assessment of brain-behavior relationships. We review the historical development of these approaches and we advocate an approach to clinical neuropsychology that is informed by recent findings from cognitive neuroscience. Clinical assessment of executive and emotional processes associated with the fr...

Paired imaging studies consisting of computed tomography (CT) and magnetic resonance imaging (MRI) were performed in eight dogs to evaluate subjectively whether MRI is superior to CT in detecting intracalvarial changes associated with canine nasal neoplasia. Imaging in four anatomical regions (caudal ethmoturbinates, cribriform plate, frontal sinuses, and the olfactory peduncle of the frontal l...