Smad ubiquitin regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that regulates transforming growth factor β (TGF-β)/Smad signaling and is implicated in a wide variety of cellular responses, but the exact mechanisms that control Smurf2 abundance are largely unknown. Here we identify microRNA-322 (miR-322) and miR-503 as novel factors that regulate Smurf2 expression posttranscriptionally. B...

We studied the effect of pH on ligand binding in wild-type lactose permease or mutants in the four residues-Glu-269, Arg-302, His-322, and Glu-325-that are the key participants in H(+) translocation and coupling between sugar and H(+) translocation. Although wild-type permease or mutants in Glu-325 and Arg-302 exhibit marked decreases in affinity at alkaline pH, mutants in either His-322 or Glu...

objective: attention-deficit/hyperactivity disorder (adhd) is a common mental disorder in adults that was under-diagnosed until recently. due to probable consequences of adhd such as occupational and educational dysfunctions and substance use, this disorder is becoming more and more of a concern. this study aimed to investigate adhd symptoms among students of zahedan university of medical scien...

abstract irregular extraction from agricultural wells around parishan lake, moreover fall of groundwater surface and water salty, would affect the level of lake water and move lake water into wells. in this study we have evaluated the externalities of extraction from agricultural wells around the lake. therefore feedback effect is considered between agricultural activity around the lake and lev...

OBJECTIVES Part A: To pilot the use of a register to identify and monitor patients with complex needs arising from long-term neurological conditions. Part B: To determine the extent to which patients' needs for health and social services are met following discharge to the community after inpatient rehabilitation; to identify which factors predict unmet needs and to explore the relationship betw...

INTRODUCTION COPD exacerbations have a negative impact on lung function, decrease quality of life (QoL) and increase the risk of death. The objective of this study was to assess the course of health status after an outpatient or inpatient exacerbation in patients with COPD. METHODS This is an epidemiological, prospective, multicentre study that was conducted in 79 hospitals and primary care c...

Burnout is one of the effective factors in reducing staff performance quality. Stress and burnout lead to quitting the job in the nursing profession to a great extent. Considering the importance of the nurses' physical and mental health and the role of burnout in nursing services quality, the present research aimed to investigate the relationship between the antecedents and burnout among the st...