Immunoreactive serum leptin was analysed in 49 women with polycystic ovary syndrome (PCOS) distributed on a wide range of body mass index (BMI; kg/m2) and in 32 normally menstruating women with comparable age, BMI, physical activity and dietary habits. All women with PCOS had increased androgen concentrations and obese women with PCOS (BMI > or = 25, n=24) also showed decreased insulin sensitiv...

Leptin resistance and obesity have been related to mutations of the leptin receptor gene in rodents and, recently, in a consanguineous family. The latter mutation results in a receptor lacking transmembrane and intracellular domains. Homozygous and heterozygous individuals with this mutation had serum leptin levels higher than expected, given their BMIs: 600, 670, and 526 ng/ml and 145, 362, 29...

Background The relationship between metabolism and reproduction has been always considered as an important topic in female endocrinology. It seems that leptin is one of the involved factors in infertility. Leptin, in addition to regulating body weight plays an important role in regulation of endocrine, reproductive and immune systems. The aim of this stduy is to compare serum and follicular flu...

Metabolic complications are prevalent in individuals treated with cranial radiotherapy (CRT) for childhood acute lymphoblastic leukemia (ALL). The hypothalamus is a master regulator of endocrine and metabolic control. The aim of this study was to investigate whether the hypothalamic volume would be associated to metabolic parameters in ALL survivors. Thirty-eight (21 women) survivors participat...

the aim of the present study was to examine the effect of aerobic training and green tea supplementation on serum leptin and insulin resistance in overweight and obese men. for this purpose, 43 overweight and obese men were selected voluntarily and were included in four groups: control (body mass index 31.4+3.7, vo2max 39.3+3.8 ml/kg.min), green tea supplement (body mass index, 30.3±2.8 k/m2, v...

AIMS Leptin plays an important role in the pathogenesis of obesity and diabetes, yet the regulatory mechanisms of this hormone have not been fully elucidated. In this study, we aimed to clarify the roles of insulin and glucose in leptin secretion and mRNA production using inhibitors of insulin signal transduction in adipocytes cultured under glucose-free or normal conditions. METHODS Differen...

Abstract Background Idiopathic intracranial hypertension (IIH) is typically seen in females of childbearing period; therefore, it possible that female sex hormones have a pathogenic role IIH. Obesity considered as strong risk factor for IIH, Leptin levels the serum and CSF were found to be positively correlated with anthropological measures obesity. The leptin pathogenesis idiopathic not fully ...