Fraser syndrome is an autosomal recessive disorder in which the life expectancy is <1 year. The main features are cryptophthalmos, ear, nose and skeletal malformations, syndactyly, laryngeal stenosis and malformation of the uro-genital system, lungs, liver and central nervous system (CNS). We report the clinical, laboratory and post-mortem findings of this condition in an elderly woman aged 96 ...

Fraser syndrome is a rare autosomal recessive genetic disorder characterized by major features such as cryptophthalmos, syndactyly, malformations of the larynx and genitourinary tract, craniofacial dysmorphism, orofacial clefting, mental retardation and musculoskeletal anomalies. In total, about 150 affected patients have been described in the literature. The diagnosis of this syndrome can be e...

Normand A. Richard, Inderjeet S. Sahota, Nadia Widmer, Sherri Ferguson, A. William Sheel, and Michael S. Koehle School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Environmental Medicine and Physiology Unit, Faculty of Science, Simon Fraser University, Burnaby, Br...

Normand A. Richard, Inderjeet S. Sahota, Nadia Widmer, Sherri Ferguson, A. William Sheel, and Michael S. Koehle School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Environmental Medicine and Physiology Unit, Faculty of Science, Simon Fraser University, Burnaby, Br...

Christian R. Marshall, Joanne A. Fox, Stefanie L. Butland, B. F. Francis Ouellette, Fiona S. L. Brinkman, and Glen F. Tibbits Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby; Cardiovascular Sciences, British Columbia Research Institute for Children’s and Women’s Health, Vancouver; Cardiac Membrane Research Laboratory, Simon Fraser University, Burnaby; and Univ...

SUMO MODIFICATION OF NATIVELY UNFOLDED PROTEINS TAU AND α-SYNUCLEIN Véronique Dorval and Paul E. Fraser From the Department of Medical Biophysics and Centre for Research in Neurodegenerative Diseases University of Toronto, Ontario, Canada Running title: Sumoylation of tau and α-synuclein Address correspondence to: Paul E. Fraser, Centre for Research in Neurodegenerative Diseases, University of ...

28 With the growing affordability of laptop computers, wireless access points, and network interface cards, it’s not surprising that so many universities have recently installed wireless networks. Students and professors are mobile, and wireless networking is a powerful technology for delivering services to these users. At Simon Fraser University, our interest in wireless networking goes back f...

Whatever else they should share, strains of bacteria assigned to the same species should have housekeeping genes that are similar in sequence. Single gene sequences (or rRNA gene sequences) have very few informative sites to resolve the strains of closely related species, and relationships among similar species may be confounded by interspecies recombination. A more promising approach (multiloc...

1 representation for guiding trail leg trajectory over an obstacle 2 3 4 by 5 6 Kim Lajoie, Leigh W. Bloomfield, Fraser J. Nelson, Jaewon J. Suh, and Daniel S. Marigold 7 8 9 Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, 10 British Columbia, Canada 11 12 13 14 Correspondence to: 15 Dr. Daniel Marigold 16 Department of Biomedical Physiology and Kinesiolog...