Protein ubiquitin modifications present a vexing analytical challenge, because of the dynamic changes in the site of modification on the substrate, the number of ubiquitin moieties attached, and the diversity of linkage patterns in which they are attached. Presented here is a method to confidently assign size and linkage type of polyubiquitin modifications. The method combines intact mass measu...

Background: Infertility is estimated to affect up to 15% of couples of reproductive age, and male factors contribute to 50% of these cases. Globozoospermia syndrome is a severe form of teratozoospermia, with an incidence of less than 0.1%. It is characterized by round sperm head. The most prominent feature of globozoospermia is the malformation of the acrosome, which is totally absent in the to...

One of the key outcomes of blasting in mines is found to be rock fragmentation which profoundly affects downstream expenses. In fact, size prediction of rock fragmentation is the first leap towards the optimization of blasting design parameters. This paper makes an attempt to present a model to predict rock fragmentation using Mutual Information (MI) in Meydook copper mine. Ten parameters are c...

Event shape distributions are determined from the data taken between 183 and 207 GeV. From these the strong coupling s is extracted in O(2 s), NLLA and matched O(2 s)+NLLA theory. Hadronisation corrections evaluated with fragmentation model generators as well as an analytical power ansatz are applied. Comparing these measurements to those obtained at and around M Z allows a combined measurement...

A measurement of the inclusive cross-section for the photoproduction of protons in the central fragmentation region at HERA is presented. The measured cross-section is compared with the prediction of the PYTHIA MC model. The obtained value of the diquark suppression factor in the Lund string model is different from that obtained in ee data. The dependence of the cross-section as a function of t...

the culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mabs) production. the quality by design (qbd) approach defines the assured quality of the final product through the development stage. an important step in qbd is determination of the main quality attributes. during the media optimization, some of the main quality attribute...

prolonged local consumption of anethum graveolens leaves, as an antihyperlipimic and antihypercholesterolemic agent, has been associated in some patients with skin disorders such as darkening and pigmentation mainly in the exposed areas such as face and hands.anethum graveolens belongs to the umbelliferae family which is belived to be rich in photoactive furocoumarins. an oraganic extract of th...