The impact of disruption of the PI3K (phosphatidylinositol 3-kinase) pathway on the response of human leukemia cells to pharmacological cyclin-dependent kinase (CDK) inhibitors has been examined. Exposure of U937 monocytic leukemia cells to minimally toxic concentrations of flavopiridol (FP), roscovitine, or CGP74514A for 3 h in conjunction with the PI3K inhibitor LY294002 (abbreviated LY in th...

Background: Spatial access has a direct effect on health service utilization in many settings. Distance to facility proven affect family planning (FP) use Sub-Saharan countries. Studies show that women who reside closer facilities offering services are more likely modern contraceptives. However, researchers often test the theory of distance decay. This study analyzed...

We derive an efficient algorithm for topographic mapping of proximity data (TMP), which can be seen as an extension of Kohonen's self-organizing map to arbitrary distance measures. The TMP cost function is derived in a Baysian framework of folded Markov chains for the description of autoencoders. It incorporates the data by a dissimilarity matrix D and the topographic neighborhood by a matrix H...

Landfill sites receive 92% of total annual solid waste produced by municipalities in the emirate of Abu Dhabi. In this study, candidate sites for an appropriate landfill location for the Abu Dhabi municipal area are determined by integrating geographic information systems (GIS) and multi-criteria evaluation (MCE) analysis. To identify appropriate landfill sites, eight input map layers including...

For Fp the field on prime number p > 3 elements, it has been conjectured that there are just p+3 evaluations of the Tutte polynomial in Fp which are computable in polynomial time. In this note it is shown that if p 6≡ −1mod 12 then there are further polynomial-time computable evaluations. 1 Definitions and introduction Let G = (V,E) denote a graph, with loops and parallel edges permitted, and G...

The effects of grazing rest on rangelands are different in different climates and knowledge of these effects is necessary to apply correct management. For this purpose, this study was carried out on the percent vegetation cover (PVC) and forage production (FP) of range species at the Nir Range Research Station in Yazd province as a model of steppe rangelands of Iran. In the study area, differen...

The reentrant pathways underlying different types of atrioventricular (AV) nodal reentrant tachycardia have not yet been elucidated. This study was performed to optically map Koch's triangle and surrounding atrial tissue in an isolated canine AV nodal preparation. Multiple preferential AV nodal input pathways were observed in all preparations (n=22) with continuous (73%, n=16) and discontinuous...

BACKGROUND AND OBJECTIVE To investigate and compare the false-positive (FP) diagnostic classification of the Bruch's membrane opening - minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc. MATERIALS AND METHODS Fifty healthy eyes of 30 participants with tilted optic disc underwent BMO-MRW and RNFL scanning using Spectralis and macu...

Frequent Itemset Mining is an important data mining task in real-world applications. Distributed parallel Apriori and FP-Growth algorithm the most that works on for finding frequent itemsets. Originally, Map-Reduce algorithm-based itemsets Hadoop were resolved. For handling big data, comes into picture but implementation of does not reach expectations distributed because its high I/O results tr...

Marine mussels attach to substrates using adhesive proteins. It has been suggested that complex coacervation (liquid-liquid phase separation via concentration) might be involved in the highly condensed and non-water dispersed adhesion process of mussel adhesive proteins (MAPs). However, as purified natural MAPs are difficult to obtain, it has not been possible to experimentally validate the coa...