Formalin-stored HEp-2 cells were used to assay Escherichia coli for adherence. Cells refrigerated in formalin for up to 28 days and used in a wet assay format demonstrated an assay sensitivity ranging from 94 to 98% to detect enteroaggregative E. coli (EAEC). HEp-2 cells first fixed and stored with formalin and then stored dry in ambient conditions for 6 weeks demonstrated an assay sensitivity ...

introduction: pain as a complex process in the cns has been extensively studied by many researchers. it has been found that pain is controlled by certain pathways in the cns, one of most important of which is the descending noradrenergic system. the pathway begins with locus coeruleus (lc) nucleus and ends in the spinal cord. in this study, formalin test was used as a chemical and tonic pain te...

introduction: pain as a complex process in central nervous system (cns) has been studied by many researchers. pain is controlled by several cns pathways, one of the most important of which, is the descending noradrenergic system. this system begins from locus coeruleus (lc) nucleus in pons and ends in the spinal cord. in this research, the effect of pain induced by formalin was studied. methods...

the amygdala is a forebrain region, which is known as a modulator of pain sensation. the amygdala, particularly the central nucleus, has high concentrations of enkephalins relative to dynorphins and has high concentrations of opioid receptors. we here studied the role of central nuclei of amygdala in morphine antinociception. methods: in this study, we used 130 male wistar rats (200- 250g). bil...

in the present study, the effects of formalin as a peripheral noxious stimulus on spontaneously active units of the nucleus reticularis paragigantocellularis (pgi), a narrow region of the ventral pontine reticular formation, was examined in urethane anesthetized rats. spontaneous discharge of the pgi neurons was variable, ranging from i to 37 spikes per second. formalin as a chemical irritant a...

UNLABELLED We sought to determine whether local administration of pentoxifylline (PTF) or propentofylline (PPTF), which hinders cytokine production, influences pain threshold and formalin-induced pain behavior in rats or the level of tumor necrosis factor-alpha (TNF-alpha) messenger RNA (mRNA) concentrations in the inflamed paw tissue. PTF (0.5, 1, or 2 mg) and PPTF (1 or 2 mg) injected intrapl...

goldfish carassius auratus were subjected to either formalin (250 ppm) or nacl (10 ppt), over a 0.5-h period followed by 24-h freshwater exposure. serum biochemistry was monitored before exposure (0), immediately after (0.5) plus 3 and 24 h after exposure. results showed that both formalin and nacl treatments caused rapid increase in cortisol with a peak at 3 h, which did not recover until 24 h...

Although glucocorticoids inhibit inflammation and are used to treat painful inflammatory rheumatic diseases, the contribution, if any, of endogenous pituitary-adrenocortical activity to the control of pain remains unclear. We report that injection of dilute formalin into the hindpaw not only evokes inflammation and pain-related behavior, but it also increases ACTH and corticosterone to a greate...