Using14C-labeled arginine to14C-labeled citrulline conversion assays in brain homogenates from 14- to 18-day-old and adult spontaneously hypertensive rats, we tested the hypotheses that maturation increases neuronal nitric oxide synthase (nNOS) activity and that this increase involves changes in cofactor availability and/or nNOS kinetics. nNOS activity (in pmol ⋅ mg-1 ⋅ min-1) was 46% higher in...

We read with interest the clinical trial reported by Sosa and others in which topical paromomycin/WR 279,369/gentamicin was compared with paromomycin alone for the treatment of New World cutaneous leishmaniasis (NWCL) caused by Leishmania panamensis. The authors concluded that the combination product may provide greater clinical benefit than paromomycin alone. The authors stated that paromomyci...

Antibody titers against Pseudomonas aeruginosa in sera from mice were markedly elevated by pre-injection of Lactobacillus casei. The number of plaque-forming cells against sheep red blood cells ( SRBC) in the spleen of mice pretreated with L. casei was highter than those in the controls. L. casei also enhanced the delayed type hypersensitivity response against SRBC in mice. Therefore, it was re...

The spherical-harmonics method, also called the PN method, is used to develop solutions to a class of multi-group or non-gray radiation transport problems. The multigroup model considered allows an anisotropic scattering law and transfer from any group to any group. In addition to a spherical-harmonics solution for the case of a homogeneous radiative-transfer equation, a particular solution for...