BACKGROUND Parathyroid metastatic disease from thyroid cancer has not been studied extensively, mainly due to the need for parathyroid preservation during thyroid surgery. METHODS We reviewed files from 1,770 patients with thyroid cancer followed up in our department and 10 patients with parathyroid metastases (0.5%) were identified. Patient and tumor characteristics were recorded. RESULTS ...

Thyroid cancer is a rare disease. Aetiological factors are increased secretion of TSH and exposure of the growing gland to ionizing radiation. Pathological classification is in two main groups: differentiated and undifferentiated. Differentiated is subdivided into papillary, follicular and medullary. Papillary and medullary carcinomas occur in young patients, grow slowly, spread by lymphatics. ...

Introduction: Patients with iodine-refractory, locally advanced or metastatic differentiated thyroid cancer usually have a poor prognosis. As new therapeutic options, tyrosine kinase inhibitors may slow down progression and stabilize the disease. The resumption of therapy after progression of the disease is questionable. Presentation of case: We report a case of a 68 year-old woman diagnosed wi...

This paper is part III of the series on thyroid disorders. Thyroid tumors are the most common endocrine neoplasms. Most of these tumors are benign hyperplastic or colloid nodules or benign follicular adenomas. However, 5% to 10% of the lesions that come to medical attention are carcinomas. A major clinical challenge is establishing which nodules are hyperplastic, benign, or malignant. History, ...

In a 59-year-old patient, thyroid follicular cancer was diagnosed in two right-sided toxic thyroid nodules, which had presented clinically as unilateral thyroid autonomy. In addition, the patient had histologically proven lung metastases of thyroid cancer; however, these failed to exhibit iodine uptake and were resistant to radioiodine treatment. The functional activity of the thyroid nodules p...

PURPOSE Cancer diagnostics and therapeutics are often based on clinically relevant markers that are expressed specifically in a malignant tissue at levels higher than in normal tissue. We examined potential markers for papillary thyroid carcinoma (PTC) by monitoring PTC-specific gene expression using cDNA microarray. EXPERIMENTAL DESIGN Gene expression profiles for PTC tissue, normal thyroid ...

Aim PSMA (prostate-specific membrane antigen) is physiologically expressed in normal prostate tissue and over expressed in prostate cancer cells, therefore constituting a potential target for antibody-based radioligand therapy. Very recent imaging findings reported PSMA-PET/CT uptake in various thyroid lesions. We were therefore encouraged to systematically analyse PSMA expression in different ...

Thyroid carcinoma is uncommon but accounts for roughly 95% of all cancers of the endocrine system (1). The "well-differentiated" thyroid tumors include the papillary, follicular, and Hurthle cell subtypes. Although the management of these tumor types generally is similar, important diagnostic and clinical differences do exist (2). We present a case of follicular thyroid carcinoma with spinal me...

The contemporary management of well-differentiated thyroid cancer requires a multidisciplinary approach involving primary care physicians, endocrinologists, surgeons, pathologists, nuclear medicine specialists, and sometimes radiologists and oncologists for diagnosis, treatment, and long-term surveillance. Well-differentiated thyroid carcinoma includes papillary and follicular thyroid carcinoma...