Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium contain ing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (1000 ng/ml) concentration of folie acid. The normal and Rous-infected fibroblasts do not differ in...

INTRODUCTION Certain 2,4-diaminopyrimidines, synthesized for possible use as metabolic antagonists, were found to have antimalarial activity (3, 5). These pyrimidines were also able to inhibit the growth of L. casei and L. citrovorum, and this effect could be reversed by folie acid or by folinic acid (4-8). For this reason it has been proposed that these pyrimi dines probably inhibited the foli...

Pseudocyesis or phantom pregnancy is a false belief of being pregnant that associated with objective signs and reported symptoms pregnancy, which may include abdominal enlargement, reduced menstrual flow, amenorrhea, subjective sensation fetal movement, nausea, breast engorgement secretions, labor. Though it very rare condition, often seen in women undergoing fertility treatment developing coun...

Methotrexate-3H (MTX-3H) was accumulated against a con centration gradient by renal cortical slices. This accumulation was energy dependent, inhibited by metabolic inhibitors, Diamox, and high concentrations of ouabain. Several folie acid analogs containing the pteridine ring were inhibitors of this accumulation while certain weak organic acids were less striking inhibitors. This suggests that ...