Mammalian TRICs function as K+-permeable cation channels that provide counter ions for Ca2+ handling in intracellular stores. Here we describe the structures of two prokaryotic homologues, archaeal SaTRIC and bacterial CpTRIC, showing that TRIC channels are symmetrical trimers with transmembrane pores through each protomer. Each pore holds a string of water molecules centred at kinked helices i...

The Turing reaction-diffusion model explains how identical cells can self-organize to form spatial patterns. It has been suggested that extracellular signaling molecules with different diffusion coefficients underlie this model, but the contribution of cell-autonomous signaling components is largely unknown. We developed an automated mathematical analysis to derive a catalog of realistic Turing...

In this paper, we introduce the concepts of n-fold obstinate pseudo-hoop and n-fold obstinate filter in pseudo-hoops. Then we investigated these notions and proved some properties of them. Also, we discussed the relationship between n-fold obstinate pseudo-hoop and n-fold obstinate filter and other types of n-fold pseudo-hoops and n-fold filters such as n-fold (positive) implicative filter and ...

The crystal structure of gpD, the capsid-stabilizing protein of bacteriophage lambda, was solved at 1.1 A resolution. Data were obtained from twinned crystals in space group P21 and refined with anisotropic temperature factors to an R-factor of 0.098 (Rfree = 0. 132). GpD (109 residues) has a novel fold with an unusually low content of regular secondary structure. Noncrystallographic trimers wi...

BACKGROUND Factors influencing differential responses of prostate tumors to androgen receptor (AR) axis-directed therapeutics are poorly understood, and predictors of treatment efficacy are needed. We hypothesized that the efficacy of inhibiting DHT ligand synthesis would associate with intra-tumoral androgen ratios indicative of relative dependence on DHT-mediated growth. METHODS We characte...

background: menopause is associated with changes in body composition in postmenopausal women. the aim of this study was to compare the effects of tibolone and continuous combined hormone therapy (ht) on body composition in postmenopausal women. materials and methods: in this randomized clinical trial, 120 menopausal women were randomly selected and divided into three groups. of these, 40 women ...

Symmetry detection is an interesting probe of pattern processing because it requires the matching of novel patterns without the benefit of prior recognition. However, there is evidence that prior knowledge of the axis location plays an important role in symmetry detection. We investigated how the prior information about the symmetry axis affects symmetry detection under noise-masking conditions...

We have constructed a poker classification system which makes informed betting decisions based upon three defining features extracted while playing poker: hand value, risk, and aggressiveness. The system is implemented as a poker player agent, and as such, the goals of the classifier are not only to correctly determine whether each hand should be folded, called, or raised, but to win as many ch...

in this study we investigate voice productions of normal speakers and patients with varying vocal fold adduction deficiencies using a noninvasive method to measure spatial vibrations of the larynx. the current version accv4 of our acceleration sensor device was used. The study’s primary goal is to find out whether lesions of vocal folds lead to additional spatial vibration modes compared to a n...