Cytokines are secreted or membrane-bound proteins that act as mediators of intercellular signaling to regulate homeostasis the immune system. They produced by cells innate and adaptive immunity in response microbes tumor antigens. Although there several studies showing IL2-330 gene polymorphism is associated with many types cancer, far we know, a few study investigating association between lung...

BACKGROUND Although the association between lead and cardiovascular disease is well established, potential mechanisms are still poorly understood. Calcium metabolism plays a role in lead toxicity and thus, vitamin D receptor (VDR) polymorphisms have been suggested to modulate the association between lead and health outcomes. We investigated effect modification by VDR genetic polymorphisms in th...

Chloroform accumulation in the body and increase its steady-state concentrations blood of exposed people have been established to be associated with polymorphisms enzyme genes a genotype involved metabolism water disinfection byproducts (A415G EPHX1 gene, C1091T CYP2E1 zero mutations GSTT1 GSTM1 genes) (р < 0.000001). These correlate higher chloroform levels consuming chlorinated drinking wa...

dna polymorphism within diacylglycerol transferase 2 (dgat2) / monoacyl glycerol transferases 2 (mogat2), leptin and butyrophilin genes were analysed using pcr-sscp in murrah buffalo. the single strand conformation polymorphism (sscp) analysis of amplified gene fragment in exon 5 of mogat2, exon 3 of leptin and intron 1 of butyrophilin gene revealed different patterns. a, b and c showed the fol...

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we als...

Introduction: Amiodarone is one of drug with narrow therapeutics index. This medicine was metabolized by CYP3A4 and CYP2C8. The changes in the activity this enzymes CYP2C8 polymorphism will affect effect. study aimed to determine impact on amiodarone responses. Method: review article search PubMed keywords: ‘amiodarone’ ‘polymorphism CYP3A4’ CYP2C8’. Results: We collect 46 references Conclusion...

In this report, β-tubulin gene polymorphism was investigated in Haemonchus contortus  populations isolated from sheep flocks in different regions of Khouzestan province, southwestern Iran. The samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. Our objective was to study the relationship between treatment background andβ -tubulin gene po...