Fluorine-containing functional groups are important motifs influencing physical and biological properties of organic compounds. Visible-light photoredox catalysis as a powerful strategy for the activation small molecules contributed significantly to rapid progress new synthetic procedures allowing introduction fluorine atoms into substrates. In this review, we highlight distinct strategies tran...

Fluorine has become an essential tool in drug discovery. Including fluorine atoms in potential medicines can have a variety of dramatic effects on the molecules' properties, perhaps making them more selective, increasing their efficacy, or making them easier to administer. So it is no great surprise that around a fifth of all drugs on the market today contain at least one fluorine substituent. ...

a series of novel 2-aminopyrimidine and 2-substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against adp and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. none of the compounds showed satisfactory activity against the aggregation induced by adp. however, satisfac...

Fluorine industry parks (FIPs) play a fundamental role in the advancement of China’s fluorine industry. In this study, Target analysis was combined with traceability to determine type PFASs present surface water and sediment around FIPs China. Meanwhile, risk they posed surrounding river examined through characterisation ratio. Among areas surveyed, 10 15 were detected sediment, concentrations ...

The assessment of tumor oxygenation is a crucial factor in cancer therapy and may be carried out using fluorine MRI once fluorine probes have been distributed within the tumor. However, the deposit of those highly fluorinated compounds often jeopardizes anatomical image quality and requires emulsification of the probes. Due to the high density and the high lipophilicity of perfluorocarbons, nan...

The research in new organic π-conjugated molecules with specific properties has become one of the most interesting topics in fields of materials chemistry. These materials are promising for optoelectronic device technology such as solar cells. On the other hand, the use of low band gap materials is a viable method for better harvesting of the solar spectrum and increasing its efficiency. The Co...

Conscious of the potential bioactivity of fluorine, an investigation was conducted using various fluorine-containing diaryliodonium salts in order to study and compare their biological activity against human lymphoma U937 cells. Most of the compounds tested are well-known reagents for fluoro-functionalized arylation reactions in synthetic organic chemistry, but their biological properties are n...

Perfluorocarbon (PFC) emulsions have been used for cell tracking studies [1, 2]; furthermore, Flögel et al. recently showed it is possible to visualize inflammation in myocardial infarction and cerebral photothrombosis (PT) mouse models using F MRI [3]. In contrast to conventional H contrast agents, F markers provide unambiguous signal in vivo due to the low natural abundance of fluorine in liv...