Acute necrotising pancreatitis in rats was induced by injecting 5% sodium taurocholate into the pancreatic duct. Prostaglandin E2 (100 micrograms/kg subcutaneously twice) decreased the mortality rate from 100% to 60% (NS). When treatment with prostaglandin E2 was combined with simultaneous administration of either dazmegrel (UK 38,485, 50 mg/kg bodyweight) or Sibelium (Flunarizine R 14,950, 0.2...

Three indirect methods for the assay of flunarizine dihydrochloride (FNH) in bulk drug and commercial formulation based on titrimetric and spectrophotometric techniques using bromate-bromide mixture are described. In titrimetry, a measured excess of bromate-bromide mixture is added to an acidified solution of FNH and the unreacted bromine is determined iodometrically (method A). Spectrophotomet...

Migraine is a common neurological disorder characterized by painful episodes sometimes preceded by transient neurological symptoms and reversible defined migraine aura. Rarer forms of migraine are hemiplegic migraine, familial and sporadic, the retinal migraine and migraine equivalents. For the two most common forms of migraine with and without aura, the prevalence appears to be higher in femal...

In a previous study we ascertained the presence of 1 and 2 recognition sites in the rabbit iris-ciliary body, an ocular structure involved in aqueous humor production and drainage. We characterized the 1 sites using the preferential ligand ( )pentazocine, which caused a significant reduction of intraocular pressure (IOP). In the present study, flunarizine, a calcium channel blocker with a compl...

The effects of flunarizine in migraine headache were investigated in 40 patients treated with single 10 mg evening doses for 16 weeks. Standard criteria were adopted for patient admission and for the monitoring of clinical (headache index, consumption of analgesics, side-effects) and laboratory variables (platelet aggregation and red cells filterability). Significant positive effects were found...

although the latter is more potent and has a isolated caudate slices by one minute longer plasma half-life.3 exposure to 20mM K' induced a tritium Given their mild D2 blocking effect in overflow of 3-9% of tissue content. Cinnaaddition to their calcium entry channe. rizine, flunarizine and nifedipine at doses antagonist activity, it has been speculated able to block calcium channels lowered the...