OBJECTIVES The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS The moisture content of MCC was optimised using the spray water method and analysed using thermog...

The low bulk density and low flowability of lignocellulosic biomass feedstock have been regarded widely as major barriers for a sustainable and efficient supply system. Densification of biomass is a viable option to increase the bulk (and inherent energy) density and flowability of feedstock, leading to improved efficiency of the supply system. The energy consumption of feedstock densification ...

Direct tableting has been renewed as a preferable process by simply mixing and compressing powder to save time and cost in comparison with granule tableting. Direct compression tableting as a technique has been successfully applied to numerous drugs on the industrial scale, although the success of any procedure, and resulting mechanical properties of tablets, is strongly affected by the quality...

Black beans (Phaseolus vulgaris L.) are a rich source of flavonoids and saponins with proven health benefits. Spray dried black bean extract powders were used in different formulations for the production of nutraceutical capsules with reduced batch-to-batch weight variability. Factorial designs were used to find an adequate maltodextrin-extract ratio for the spray-drying process to produce blac...

NiCrMoY alloy powders were prepared using inert gas atomization by incorporation of rare earth elements, such as Mo, Nb, and Y into Ni60A powders, the coatings were sprayed by oxy-acetylene flame spray and then remelted with high-frequency induction. The morphologies, hollow particle ratio, particle-size distribution, apparent density, flowability, and the oxygen content of the NiCrMoY alloy po...

The aim of present study was to prepare and characterize the recrystallized agglomerates of water insoluble non steroidal anti-inflammatory drug, indomethacin (IM) with hydrophilic polymers like polyvinyl pyrrolidone (PVP),hydroxyl ethyl cellulose (HEC) and hydroxyl propyl methyl cellulose (HPMC) by using emulsion solvent diffusion (ESD) technique for enhancing the solubility, dissolution rate,...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (CP) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation metho...

PURPOSE The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. METHODS In this study, 13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and granules was studied. Then effervescen...

Controlling the powder flow by surface properties of particles as well understanding their flowability under different processing dynamics are amongst major challenges industry. Indeed, handling large quantities needs powders with good flowability, adequate compressibility and few electrostatic charges. We have performed a chemical treatment in order to obtain hydrophobic glass bead its bulk be...

This paper presents an extraction and microencapsulation study of polyphenols obtained from Orthosiphon stamineus leaves. Extraction using aqueous solvent enabled a simultaneous extraction of both hydrophilic and lipophilic phenolic compounds. Higher solid concentration leads to higher solution viscosity, bigger particle size, lower moisture content and a less dented surface, which may improve ...