Floating matrix tablets or stomach specific drug delivery systems are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug, especially useful for achieving controlled plasma level as well as improving bioavailability. Due to low gastric retention time, the bioavailability of acyclovir is low as the large portion of dr...

Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets...

Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

The purpose of the study was to prolong the gastric residence time and increase the bioavailability of atenolol by designing its floating tablets and to study the influence of different polymers on its release rate. It was selected as a model drug, because it is poorly absorbed from the lower GIT. The tablets were prepared by direct compression technique, using different polymers such as hydrox...

Objective: The objective of the present study was to formulate a controlled release floating tablet of Olmesartan Medoxomil. Methods: Floating tablets of Olmesartan Medoxomil were prepared by direct compression method using both natural (sodium alginate and carrageenan) and semi synthetic polymers (HPMC K4M, HPMC K100LV and HPMC E50LV).Sodium bicarbonate and calcium carbonate were used as gas g...

Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50...

Gastroretentive tablets of propranolol hydrochloride were developed by direct compression method using citric acid and sodium bicarbonate as the effervescent base. Hydroxypropyl methylcellulose; HPMC K15M was used to prepare the floating tablets to retard the drug release for 12h in stomach. Na-carboxymethyl cellulose (NaCMC) or carbopol 934P was added to alter the drug release profile or the d...