Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

We consider general discrete-time nonlinear systems (of arbitrary nonlinear growth) with time-varying input delays and design an explicit predictor feedback controller to compensate the input delay. Such results have been achieved in continuous time, but only under the restriction that the delay rate is bounded by unity, which ensures that the input signal flow does not get reversed, namely, th...

in this paper, the problem of finite time stabilization for guidance system is investigated and a novel nonlinear guidance law against maneuvering targets is proposed based on the principles of parallel navigation. the proposed law is developed using two variable structure control techniques. by applying finite time integral sliding mode and combining it with terminal sliding mode, a new guidan...

This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects release retardant on in vitro drug release. is β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, Anti Angina. has 48% oral bioavailability due limited absorption from lower gastrointestinal tract. The tablets were designed increase stomach retention, prolong release,...

Robustness is established for the predictor feedback for linear time-invariant systems with respect to possibly time-varying perturbations of the input delay, with a constant nominal delay. The prior results have addressed qualitatively constant delay perturbations (robustness of stability in L2 norm of actuator state) and delay perturbations with restricted rate of change (robustness of stabil...

This paper presents methods for estimating time delay margin for adaptive control of input delay systems with almost linear structured uncertainty. The bounded linear stability analysis method seeks to represent an adaptive law by a locally bounded linear approximation within a small time window. The time delay margin of this input delay system represents a local stability measure and is comput...