In the current study, wet granulation with various concentrations and combinations of excipients like magnesium stearate as a lubricant, talc glident, DCP diluent, PVP K 30 binder successfully produced floating tablets rosiglitazone maleate. These included HPMC K15M, xanthan gum, sodium bicarbonate, tartaric acid gas-generating agents. We investigated every pre-compressional parameter, includin...

abstract                                                                               the new drug delivery systems have been developed, which can remain in the stomach for prolonged period of time. the effervescent floating tablet is one of these systems. iron deficiency anaemia is a common disease in the world. ferrous sulphate is the most common ferrous preparation used to treat and prevent...

Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which...

Novel drug delivery system overcomes the physiological problems of gastric retention by decreasing fluctuations in blood drug concentration with consequent reduction in undesirable toxicity and poor efficiency. Incorporation of drug in controlled release gastroretentive dosage forms which can remain in the gastric region for several hours would significantly prolong the gastric residence time o...

The purpose of this research was to prepare and evaluate floating drug delivery system of Lamivudine. Floating matrix tablets of Lamivudine were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administe...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...