Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer's disease is the decrease in the level of acetylcholine. Available drugs that are used for the treatment of Alzheimer's disease are primarily acetylcholinesterase inhibitors with ...

In young plants of Eucalyptus globulus the leaves are covered with a whitish epicuticular layer. This leaf wax contains small amounts of C-methylated flavones as aglycones. A novel flavone has now been identified as 5,4'-dihydroxy, 7-methoxy, 6-methyl-flavone (8-desmethyl-sideroxylin). Another minor external flavone is chrysin. On leaves of E. sieberi the flavanone pinocembrin could be detected...

We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent ne...

Antioxidant properties of substrates [flavanone (1), 6-hydroxy- (2), 7-hydroxy- (3), 5,7,4'-trihydroxy- (5), and 7-methoxyflavanone (4)] and products of their microbial transformations, comprising hydroxylation, O-methylation, stereospecific reduction, dehydrogenation, and C-ring cleavage of the benzo-gamma-pyrone system, were determined. Measurements of the antiradical activity (expressed as I...