Anticancer drug combinations can act synergistically or antagonistically against tumor cells in vitro depending on the ratios of the individual agents comprising the combination. The importance of drug ratios in vivo, however, has heretofore not been investigated, and combination chemotherapy treatment regimens continue to be developed based on the maximum tolerated dose of the individual agent...

-Fixed-outline floorplanning enables multilevel hierarchical design, where aspect ratios and area of floorplans are usually imposed by higher level floorplanning and must be satisfied. Simulated Annealing is widely used in the floorplanning problem. It is well-known that the solution space, solution perturbation, and objective function are very important for Simulated Annealing. In this paper, ...

The sequence obtained to solve this problem—the celebrated Fibonacci sequence 1, 1, 2, 3, 5, 8, 13, 21, ...—appears in a large number of natural phenomena (see [2], [6]) and has natural applications in computer science (see [1]). Here we reformulate the rabbit problem to recover two generalizations of the Fibonacci sequence presented elsewhere (see [7], [8]). Then, using a fixed-point technique...

suspended particles with aerodynamic diameters not greater than 2.5 μm (pm2.5) were sampledat the urban background, regional background and urban traffic points in southern poland. in total, 120 sampleswere collected between 2nd august 2009 and 27th december 2010. 16 polycyclic aromatic hydrocarbons (pahs)and organic carbon (oc) were determined in each sample. the samples were collected with a ...

Constructal design is used to study heat removal from a square heated body with a tree shaped high thermal conductivity pathways embedded in the body. The objective is to minimize the defined maximum dimensionless temperature difference for the body. The thermal conductivity of the body is low, and there is a uniform heat generation on it. The volume of the body is fixed. The amount of high con...

background and aims. the correct relationship of the total mesiodistal width of the mandibular teeth to that of the maxillary teeth (bolton’s ratios) is among the main factors considered in obtaining an optimal occlusion. the present study was conducted to determining the bolton’s ratios before and after treatment in skeletal class i patients. materials and methods. in this descriptive analytic...

A shortcut procedure as quick, easy-to use method for design and simulation of multicomponent batch distillation is used to predict the operating condition of recovering xylene from solvent in an existing batch distillation column in benzol refinery. The procedure can be used to investigate the effect of the operating parameters on the operation of column for three possible modes of batch d...