Saccharomyces cerevisiae CDC7 encodes a serine/threonine kinase required for G(1)/S transition, and its related kinases are present in fission yeast as well as in higher eukaryotes, including humans. Kinase activity of Cdc7 protein depends on the regulatory subunit, Dbf4, which also interacts with replication origins. We have identified him1(+) from two-hybrid screening with Hsk1, a fission yea...

Mitochondria are dynamic organelles, undergoing both fission and fusion regularly in interphase cells. Mitochondrial fission is thought to be part of a quality-control mechanism whereby damaged mitochondrial components are segregated from healthy components in an individual mitochondrion, followed by mitochondrial fission and degradation of the damaged daughter mitochondrion. Fission also plays...

The yeast protein Fis1p has been shown to participate in mitochondrial fission mediated by the dynamin-related protein Dnm1p. In mammalian cells, the dynamin-like protein DLP1/Drp1 functions as a mitochondrial fission protein, but the mechanisms by which DLP1/Drp1 and the mitochondrial membrane interact during the fission process are undefined. In this study, we have tested the role of a mammal...

Singlet exciton fission allows the fast and efficient generation of two spin triplet states from one photoexcited singlet. It has the potential to improve organic photovoltaics, enabling efficient coupling to the blue to ultraviolet region of the solar spectrum to capture the energy generally lost as waste heat. However, many questions remain about the underlying fission mechanism. The relation...

In this preliminary scoping study, post-accident temperature transients of several fusion-fission designs utilizing ITER-FEAT-like parameters and fission pebble bed fuel technology are examined using a 1-D cylindrical Matlab heat transfer code along with conventional fission decay heat approximations. Scenarios studied include systems with no additional passive safety features to systems with m...

This paper presents an application of the Fusion-Fission method to the multi-way graph partitioning problem. The Fusion-Fission method was first designed to solve the normalized cut partitioning problem. Its application to the multi-way graph partitioning problem is very recent, thus the Fusion-Fission algorithm has not yet been optimized. Then, the Fusion-Fission algorithm is slower than the s...

Mitochondrial fission and fusion are linked to synaptic activity in healthy neurons and are implicated in the regulation of apoptotic cell death in many cell types. We developed fluorescence microscopy and computational strategies to directly measure mitochondrial fission and fusion frequencies and their effects on mitochondrial morphology in cultured neurons. We found that the rate of fission ...

Studies of transmutation of long-lived fission products by accelerator and by fission reactor at PNC are described. Four transmutation methods by accelerators are compared in terms of transmutation energy and transmutation rate. A super-powered electron linear accelerator which could transmute a large quantity of fission products has been studied and development of PNC test linac in this line i...

Singlet fission, a spin-allowed energy transfer process generating two triplet excitons from one singlet exciton, has the potential to dramatically increase the efficiency of organic solar cells. However, the dynamical mechanism of this phenomenon is not fully understood and a complete, microscopic theory of singlet fission is lacking. In this work, we assemble the components of a comprehensive...

The results of model calculations on nuclide yields produced by fission of excited U nuclei are presented. The calculation combines the modelling of the deexcitation process including the fission competition with the prediction of the nuclide production in the fission of excited U and all daughter nuclei produced in the evaporation cascade. The calculations are relevant for the design of future...